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- NCIT_C116845 IAO_0000115 "A small molecule inhibitor of cell cycle checkpoint kinase 1 (Chk1), with potential chemosensitization activity. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. Therefore, Chk1 inhibition may sensitize tumor cells to the DNA-damaging effects of certain chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that phosphorylates cdc25 phosphatases in response to DNA damage. This results in both inhibitory tyrosine phosphorylation of cyclin-dependent kinase (CDK)-cyclin complexes and cell cycle arrest, which facilitates DNA damage repair." @default.
- NCIT_C116845 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116845 NCIT_A7 NCIT_C25919 @default.
- NCIT_C116845 NCIT_NHC0 "C116845" @default.
- NCIT_C116845 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116845 NCIT_P107 "Chk1 Inhibitor GDC-0575" @default.
- NCIT_C116845 NCIT_P108 "Chk1 Inhibitor GDC-0575" @default.
- NCIT_C116845 NCIT_P208 "CL446611" @default.
- NCIT_C116845 NCIT_P322 "CTRP" @default.
- NCIT_C116845 NCIT_P322 "GDC" @default.
- NCIT_C116845 NCIT_P329 "730054" @default.
- NCIT_C116845 NCIT_P330 "730054" @default.
- NCIT_C116845 NCIT_P375 "Chk1 Inhibitor GDC-0575" @default.
- NCIT_C116845 NCIT_P399 "730054" @default.
- NCIT_C116845 normalizedInformationContent "100" @default.
- NCIT_C116845 referenceCount "1" @default.
- NCIT_C116845 hasExactSynonym "Checkpoint Kinase 1 Inhibitor GDC-0575" @default.
- NCIT_C116845 hasExactSynonym "Chk1 Inhibitor GDC-0575" @default.
- NCIT_C116845 hasExactSynonym "GDC-0575" @default.
- NCIT_C116845 inSubset NCIT_C116977 @default.
- NCIT_C116845 inSubset NCIT_C116978 @default.
- NCIT_C116845 inSubset NCIT_C128784 @default.
- NCIT_C116845 inSubset NCIT_C157711 @default.
- NCIT_C116845 inSubset NCIT_C157712 @default.
- NCIT_C116845 inSubset NCIT_C176424 @default.
- NCIT_C116845 inSubset NCIT_C177537 @default.
- NCIT_C116845 type Class @default.
- NCIT_C116845 isDefinedBy ncit.owl @default.
- NCIT_C116845 label "Chk1 Inhibitor GDC-0575" @default.
- NCIT_C116845 subClassOf NCIT_C116845 @default.
- NCIT_C116845 subClassOf NCIT_C129824 @default.
- NCIT_C116845 subClassOf NCIT_C129825 @default.
- NCIT_C116845 subClassOf NCIT_C1404 @default.
- NCIT_C116845 subClassOf NCIT_C155927 @default.
- NCIT_C116845 subClassOf NCIT_C1908 @default.
- NCIT_C116845 subClassOf NCIT_C1909 @default.
- NCIT_C116845 subClassOf NCIT_C2189 @default.
- NCIT_C116845 subClassOf NCIT_C274 @default.
- NCIT_C116845 subClassOf NCIT_C471 @default.
- NCIT_C116845 subClassOf NCIT_C61074 @default.