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- NCIT_C116851 IAO_0000115 "An orally active and small molecule inhibitor of heat shock protein 90 (Hsp90), with potential antineoplastic activity. Upon oral administration, Hsp90 inhibitor DS-2248 specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may lead to an inhibition of tumor cell proliferation. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins." @default.
- NCIT_C116851 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116851 NCIT_A7 NCIT_C17766 @default.
- NCIT_C116851 NCIT_NHC0 "C116851" @default.
- NCIT_C116851 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116851 NCIT_P107 "Hsp90 Inhibitor DS-2248" @default.
- NCIT_C116851 NCIT_P108 "Hsp90 Inhibitor DS-2248" @default.
- NCIT_C116851 NCIT_P208 "CL433776" @default.
- NCIT_C116851 NCIT_P210 "1015051-35-0" @default.
- NCIT_C116851 NCIT_P319 "3HJ2545H66" @default.
- NCIT_C116851 NCIT_P322 "CTRP" @default.
- NCIT_C116851 NCIT_P322 "FDA" @default.
- NCIT_C116851 NCIT_P322 "GDC" @default.
- NCIT_C116851 NCIT_P329 "694996" @default.
- NCIT_C116851 NCIT_P330 "694996" @default.
- NCIT_C116851 NCIT_P375 "Hsp90 Inhibitor DS-2248" @default.
- NCIT_C116851 NCIT_P399 "694996" @default.
- NCIT_C116851 NCIT_R125 NCIT_C17828 @default.
- NCIT_C116851 NCIT_R125 NCIT_C20150 @default.
- NCIT_C116851 NCIT_R125 NCIT_C20480 @default.
- NCIT_C116851 NCIT_R125 NCIT_C40715 @default.
- NCIT_C116851 NCIT_R125 NCIT_C41515 @default.
- NCIT_C116851 NCIT_R125 NCIT_C51037 @default.
- NCIT_C116851 normalizedInformationContent "100" @default.
- NCIT_C116851 referenceCount "1" @default.
- NCIT_C116851 hasExactSynonym "DS-2248" @default.
- NCIT_C116851 hasExactSynonym "Heat Shock Protein 90 Inhibitor DS-2248" @default.
- NCIT_C116851 hasExactSynonym "Hsp90 Inhibitor DS-2248" @default.
- NCIT_C116851 inSubset NCIT_C116977 @default.
- NCIT_C116851 inSubset NCIT_C116978 @default.
- NCIT_C116851 inSubset NCIT_C128784 @default.
- NCIT_C116851 inSubset NCIT_C157711 @default.
- NCIT_C116851 inSubset NCIT_C157712 @default.
- NCIT_C116851 inSubset NCIT_C176424 @default.
- NCIT_C116851 inSubset NCIT_C177537 @default.
- NCIT_C116851 inSubset NCIT_C63923 @default.
- NCIT_C116851 type Class @default.
- NCIT_C116851 isDefinedBy ncit.owl @default.
- NCIT_C116851 label "Hsp90 Inhibitor DS-2248" @default.
- NCIT_C116851 subClassOf NCIT_C116851 @default.
- NCIT_C116851 subClassOf NCIT_C129824 @default.
- NCIT_C116851 subClassOf NCIT_C156880 @default.
- NCIT_C116851 subClassOf NCIT_C1908 @default.
- NCIT_C116851 subClassOf NCIT_C1909 @default.
- NCIT_C116851 subClassOf NCIT_C2189 @default.
- NCIT_C116851 subClassOf NCIT_C274 @default.
- NCIT_C116851 subClassOf NCIT_C74526 @default.