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- NCIT_C116852 IAO_0000115 "A human monoclonal antibody directed against type II activin receptors (ActRII; ActR2), with potential muscle-sparing and anti-cachectic activities. Upon administration, bimagrumab binds to ActRII, which prevents the binding of the natural ligands, myostatin and activin, to activin receptors and blocks ActRII-mediated signaling. This increases protein synthesis, decreases protein degradation, stimulates skeletal muscle cell growth, and increases muscle function and strength. Overstimulation of the ActRII-mediated signaling pathway is associated with muscle loss and weakness." @default.
- NCIT_C116852 NCIT_NHC0 "C116852" @default.
- NCIT_C116852 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C116852 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116852 NCIT_P107 "Bimagrumab" @default.
- NCIT_C116852 NCIT_P108 "Bimagrumab" @default.
- NCIT_C116852 NCIT_P207 "C3899948" @default.
- NCIT_C116852 NCIT_P210 "1356922-05-8" @default.
- NCIT_C116852 NCIT_P319 "N15SW1DIV8" @default.
- NCIT_C116852 NCIT_P322 "CTRP" @default.
- NCIT_C116852 NCIT_P322 "FDA" @default.
- NCIT_C116852 NCIT_P329 "712059" @default.
- NCIT_C116852 NCIT_P330 "712059" @default.
- NCIT_C116852 NCIT_P399 "712059" @default.
- NCIT_C116852 NCIT_R124 NCIT_C17710 @default.
- NCIT_C116852 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116852 NCIT_R124 NCIT_C18219 @default.
- NCIT_C116852 NCIT_R124 NCIT_C19986 @default.
- NCIT_C116852 NCIT_R124 NCIT_C40474 @default.
- NCIT_C116852 normalizedInformationContent "100" @default.
- NCIT_C116852 referenceCount "1" @default.
- NCIT_C116852 hasExactSynonym "BIMAGRUMAB" @default.
- NCIT_C116852 hasExactSynonym "BYM338" @default.
- NCIT_C116852 hasExactSynonym "Bimagrumab" @default.
- NCIT_C116852 hasExactSynonym "HuCAL-based Antibody BYM338" @default.
- NCIT_C116852 hasExactSynonym "Human Combinatorial Antibody Library-based Monoclonal Antibody BYM338" @default.
- NCIT_C116852 inSubset NCIT_C116977 @default.
- NCIT_C116852 inSubset NCIT_C116978 @default.
- NCIT_C116852 inSubset NCIT_C176424 @default.
- NCIT_C116852 inSubset NCIT_C63923 @default.
- NCIT_C116852 type Class @default.
- NCIT_C116852 isDefinedBy ncit.owl @default.
- NCIT_C116852 label "Bimagrumab" @default.
- NCIT_C116852 subClassOf NCIT_C116852 @default.
- NCIT_C116852 subClassOf NCIT_C1908 @default.
- NCIT_C116852 subClassOf NCIT_C1909 @default.
- NCIT_C116852 subClassOf NCIT_C20401 @default.
- NCIT_C116852 subClassOf NCIT_C307 @default.
- NCIT_C116852 subClassOf NCIT_C308 @default.