Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C116853> ?p ?o ?g. }
Showing items 1 to 26 of
26
with 100 items per page.
- NCIT_C116853 IAO_0000115 "A hyperpolarized pyruvate labeled with carbon C 13, with potential usage in the diagnostic imaging of cancer cells. Upon administration, carbon C 13 hyperpolarized pyruvate (13C-pyruvate) is taken up by cancer cells and is further metabolized to lactate and alanine for use in glycolysis, lipogenesis and protein synthesis, to support the enhanced metabolic needs of tumor cells. As tumor cells are rapidly proliferating, their uptake of pyruvate and its subsequent conversion to alanine and lactate are higher than non-proliferating cells. Upon nuclear magnetic resonance (NMR)-based imaging (MRI), both hyperpolarized 13C-pyruvate as well as its metabolites can be detected and visualized in cancer cells; this may aid in the diagnosis of cancer. Hyperpolarization of 13C-pyruvate, using dynamic nuclear polarization (DNP), enhances NMR signals." @default.
- NCIT_C116853 NCIT_NHC0 "C116853" @default.
- NCIT_C116853 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116853 NCIT_P107 "Hyperpolarized Carbon C 13 Pyruvate" @default.
- NCIT_C116853 NCIT_P108 "Hyperpolarized Carbon C 13 Pyruvate" @default.
- NCIT_C116853 NCIT_P208 "CL433740" @default.
- NCIT_C116853 NCIT_P322 "CTRP" @default.
- NCIT_C116853 NCIT_P329 "688700" @default.
- NCIT_C116853 NCIT_P330 "688700" @default.
- NCIT_C116853 NCIT_P399 "688700" @default.
- NCIT_C116853 normalizedInformationContent "100" @default.
- NCIT_C116853 referenceCount "1" @default.
- NCIT_C116853 hasExactSynonym "Hyperpolarized 13C-Pyruvate" @default.
- NCIT_C116853 hasExactSynonym "Hyperpolarized Carbon C 13 Pyruvate" @default.
- NCIT_C116853 hasExactSynonym "Hyperpolarized Pyruvate (13C)" @default.
- NCIT_C116853 inSubset NCIT_C116977 @default.
- NCIT_C116853 inSubset NCIT_C116978 @default.
- NCIT_C116853 inSubset NCIT_C176424 @default.
- NCIT_C116853 type Class @default.
- NCIT_C116853 isDefinedBy ncit.owl @default.
- NCIT_C116853 label "Hyperpolarized Carbon C 13 Pyruvate" @default.
- NCIT_C116853 subClassOf NCIT_C116853 @default.
- NCIT_C116853 subClassOf NCIT_C1446 @default.
- NCIT_C116853 subClassOf NCIT_C1908 @default.
- NCIT_C116853 subClassOf NCIT_C1909 @default.
- NCIT_C116853 subClassOf NCIT_C2124 @default.