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- NCIT_C116858 IAO_0000115 "An orally available inhibitor of FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), the tyrosine kinase ABL, and aurora kinases, with potential antineoplastic activity. Upon administration, FLT3/ABL/Aurora kinase inhibitor KW-2449 specifically binds to and inhibits both wild-type and mutated forms of FLT3, ABL and aurora kinases, which both interferes with the activation of signal transduction pathways mediated by these kinases and reduces the proliferation of susceptible cancer cells. FLT3 and ABL kinases are upregulated in certain tumor cells and play important roles in tumor cell proliferation and metastasis. Aurora kinases, serine-threonine kinases overexpressed by a wide variety of cancer cell types, play essential roles in mitotic checkpoint control." @default.
- NCIT_C116858 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116858 NCIT_NHC0 "C116858" @default.
- NCIT_C116858 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116858 NCIT_P107 "FLT3/ABL/Aurora Kinase Inhibitor KW-2449" @default.
- NCIT_C116858 NCIT_P108 "FLT3/ABL/Aurora Kinase Inhibitor KW-2449" @default.
- NCIT_C116858 NCIT_P207 "C1831922" @default.
- NCIT_C116858 NCIT_P210 "841258-76-2" @default.
- NCIT_C116858 NCIT_P319 "2D9N67F58G" @default.
- NCIT_C116858 NCIT_P322 "CTRP" @default.
- NCIT_C116858 NCIT_P322 "FDA" @default.
- NCIT_C116858 NCIT_P322 "GDC" @default.
- NCIT_C116858 NCIT_P329 "496931" @default.
- NCIT_C116858 NCIT_P330 "496931" @default.
- NCIT_C116858 NCIT_P375 "FLT3/ABL/Aurora Kinase Inhibitor KW-2449" @default.
- NCIT_C116858 NCIT_P399 "496931" @default.
- NCIT_C116858 normalizedInformationContent "100" @default.
- NCIT_C116858 referenceCount "1" @default.
- NCIT_C116858 hasExactSynonym "FLT3/ABL/Aurora Kinase Inhibitor KW-2449" @default.
- NCIT_C116858 hasExactSynonym "KW-2449" @default.
- NCIT_C116858 inSubset NCIT_C116977 @default.
- NCIT_C116858 inSubset NCIT_C116978 @default.
- NCIT_C116858 inSubset NCIT_C128784 @default.
- NCIT_C116858 inSubset NCIT_C157711 @default.
- NCIT_C116858 inSubset NCIT_C157712 @default.
- NCIT_C116858 inSubset NCIT_C176424 @default.
- NCIT_C116858 inSubset NCIT_C177537 @default.
- NCIT_C116858 inSubset NCIT_C63923 @default.
- NCIT_C116858 type Class @default.
- NCIT_C116858 isDefinedBy ncit.owl @default.
- NCIT_C116858 label "FLT3/ABL/Aurora Kinase Inhibitor KW-2449" @default.
- NCIT_C116858 subClassOf NCIT_C116858 @default.
- NCIT_C116858 subClassOf NCIT_C129824 @default.
- NCIT_C116858 subClassOf NCIT_C129825 @default.
- NCIT_C116858 subClassOf NCIT_C1404 @default.
- NCIT_C116858 subClassOf NCIT_C1908 @default.
- NCIT_C116858 subClassOf NCIT_C1909 @default.
- NCIT_C116858 subClassOf NCIT_C2189 @default.
- NCIT_C116858 subClassOf NCIT_C274 @default.
- NCIT_C116858 subClassOf NCIT_C471 @default.