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- NCIT_C116860 IAO_0000115 "An orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, WNT974 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers." @default.
- NCIT_C116860 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116860 NCIT_A7 NCIT_C132191 @default.
- NCIT_C116860 NCIT_NHC0 "C116860" @default.
- NCIT_C116860 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116860 NCIT_P107 "Porcupine Inhibitor WNT974" @default.
- NCIT_C116860 NCIT_P108 "Porcupine Inhibitor WNT974" @default.
- NCIT_C116860 NCIT_P207 "C3851400" @default.
- NCIT_C116860 NCIT_P210 "1243244-14-5" @default.
- NCIT_C116860 NCIT_P319 "U27F40013Q" @default.
- NCIT_C116860 NCIT_P322 "CTRP" @default.
- NCIT_C116860 NCIT_P322 "FDA" @default.
- NCIT_C116860 NCIT_P322 "GDC" @default.
- NCIT_C116860 NCIT_P329 "700477" @default.
- NCIT_C116860 NCIT_P330 "700477" @default.
- NCIT_C116860 NCIT_P375 "Porcupine Inhibitor WNT974" @default.
- NCIT_C116860 NCIT_P399 "700477" @default.
- NCIT_C116860 normalizedInformationContent "100" @default.
- NCIT_C116860 referenceCount "1" @default.
- NCIT_C116860 hasExactSynonym "2-(2,3-Dimethyl-[2,4-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide" @default.
- NCIT_C116860 hasExactSynonym "LGK974" @default.
- NCIT_C116860 hasExactSynonym "PORCN inhibitor LGK974" @default.
- NCIT_C116860 hasExactSynonym "Porcupine Inhibitor WNT974" @default.
- NCIT_C116860 hasExactSynonym "WNT-974" @default.
- NCIT_C116860 hasExactSynonym "WNT974" @default.
- NCIT_C116860 inSubset NCIT_C116977 @default.
- NCIT_C116860 inSubset NCIT_C116978 @default.
- NCIT_C116860 inSubset NCIT_C128784 @default.
- NCIT_C116860 inSubset NCIT_C157711 @default.
- NCIT_C116860 inSubset NCIT_C157712 @default.
- NCIT_C116860 inSubset NCIT_C176424 @default.
- NCIT_C116860 inSubset NCIT_C177537 @default.
- NCIT_C116860 inSubset NCIT_C63923 @default.
- NCIT_C116860 type Class @default.
- NCIT_C116860 isDefinedBy ncit.owl @default.
- NCIT_C116860 label "Porcupine Inhibitor WNT974" @default.
- NCIT_C116860 subClassOf NCIT_C116860 @default.
- NCIT_C116860 subClassOf NCIT_C1908 @default.
- NCIT_C116860 subClassOf NCIT_C1909 @default.
- NCIT_C116860 subClassOf NCIT_C471 @default.