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- NCIT_C116861 IAO_0000115 "An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon administration, pan-RAF kinase inhibitor LY3009120 inhibits Raf-mediated signal transduction pathways, which may inhibit tumor cell growth. Raf protein kinases play a key role in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway, which is often dysregulated in human cancers and plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C116861 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116861 NCIT_A7 NCIT_C17476 @default.
- NCIT_C116861 NCIT_A7 NCIT_C17484 @default.
- NCIT_C116861 NCIT_A7 NCIT_C18535 @default.
- NCIT_C116861 NCIT_NHC0 "C116861" @default.
- NCIT_C116861 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116861 NCIT_P107 "Pan-RAF Inhibitor LY3009120" @default.
- NCIT_C116861 NCIT_P108 "Pan-RAF Inhibitor LY3009120" @default.
- NCIT_C116861 NCIT_P207 "C3896821" @default.
- NCIT_C116861 NCIT_P210 "1454682-72-4" @default.
- NCIT_C116861 NCIT_P319 "1GDT36RARO" @default.
- NCIT_C116861 NCIT_P322 "CTRP" @default.
- NCIT_C116861 NCIT_P322 "FDA" @default.
- NCIT_C116861 NCIT_P322 "GDC" @default.
- NCIT_C116861 NCIT_P329 "756062" @default.
- NCIT_C116861 NCIT_P330 "756062" @default.
- NCIT_C116861 NCIT_P375 "Pan-RAF Inhibitor LY3009120" @default.
- NCIT_C116861 NCIT_P399 "756062" @default.
- NCIT_C116861 normalizedInformationContent "100" @default.
- NCIT_C116861 referenceCount "1" @default.
- NCIT_C116861 hasExactSynonym "DP-4978" @default.
- NCIT_C116861 hasExactSynonym "LY-3009120" @default.
- NCIT_C116861 hasExactSynonym "LY3009120" @default.
- NCIT_C116861 hasExactSynonym "Pan-RAF Inhibitor LY3009120" @default.
- NCIT_C116861 inSubset NCIT_C116977 @default.
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- NCIT_C116861 inSubset NCIT_C177537 @default.
- NCIT_C116861 inSubset NCIT_C63923 @default.
- NCIT_C116861 type Class @default.
- NCIT_C116861 isDefinedBy ncit.owl @default.
- NCIT_C116861 label "Pan-RAF Inhibitor LY3009120" @default.
- NCIT_C116861 subClassOf NCIT_C116861 @default.
- NCIT_C116861 subClassOf NCIT_C129824 @default.
- NCIT_C116861 subClassOf NCIT_C129825 @default.
- NCIT_C116861 subClassOf NCIT_C1404 @default.
- NCIT_C116861 subClassOf NCIT_C163758 @default.
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- NCIT_C116861 subClassOf NCIT_C2189 @default.
- NCIT_C116861 subClassOf NCIT_C2336 @default.
- NCIT_C116861 subClassOf NCIT_C274 @default.
- NCIT_C116861 subClassOf NCIT_C471 @default.
- NCIT_C116861 subClassOf NCIT_C61074 @default.