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- NCIT_C116866 IAO_0000115 "An orally bioavailable inhibitor of c-Met, with potential antineoplastic activity. Upon administration, c-Met inhibitor MK8033 binds to and inhibits the autophosphorylation of the c-Met protein, which disrupts c-Met signal transduction pathways and may induce cell death in tumor cells overexpressing or expressing constitutively activated c-Met protein. In addition, MK8033 inhibits Ron (receptor originated from nantes, MST1R). c-Met protein, which is encoded by the proto-oncogene MET, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. Ron, a member of the Met family of cell surface receptor tyrosine kinases, is also overexpressed on certain tumor cell types." @default.
- NCIT_C116866 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116866 NCIT_A7 NCIT_C18186 @default.
- NCIT_C116866 NCIT_NHC0 "C116866" @default.
- NCIT_C116866 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116866 NCIT_P107 "c-Met Inhibitor MK8033" @default.
- NCIT_C116866 NCIT_P108 "c-Met Inhibitor MK8033" @default.
- NCIT_C116866 NCIT_P207 "C3659325" @default.
- NCIT_C116866 NCIT_P210 "1196681-38-5" @default.
- NCIT_C116866 NCIT_P319 "350H6PBQ5Q" @default.
- NCIT_C116866 NCIT_P322 "CTRP" @default.
- NCIT_C116866 NCIT_P322 "FDA" @default.
- NCIT_C116866 NCIT_P322 "GDC" @default.
- NCIT_C116866 NCIT_P329 "580991" @default.
- NCIT_C116866 NCIT_P330 "580991" @default.
- NCIT_C116866 NCIT_P375 "c-Met Inhibitor MK8033" @default.
- NCIT_C116866 NCIT_P399 "580991" @default.
- NCIT_C116866 normalizedInformationContent "100" @default.
- NCIT_C116866 referenceCount "1" @default.
- NCIT_C116866 hasExactSynonym "1-(3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide" @default.
- NCIT_C116866 hasExactSynonym "MK 8033" @default.
- NCIT_C116866 hasExactSynonym "MK-8033" @default.
- NCIT_C116866 hasExactSynonym "MK8033" @default.
- NCIT_C116866 hasExactSynonym "c-Met Inhibitor MK8033" @default.
- NCIT_C116866 inSubset NCIT_C116977 @default.
- NCIT_C116866 inSubset NCIT_C116978 @default.
- NCIT_C116866 inSubset NCIT_C128784 @default.
- NCIT_C116866 inSubset NCIT_C157711 @default.
- NCIT_C116866 inSubset NCIT_C157712 @default.
- NCIT_C116866 inSubset NCIT_C176424 @default.
- NCIT_C116866 inSubset NCIT_C177537 @default.
- NCIT_C116866 inSubset NCIT_C63923 @default.
- NCIT_C116866 type Class @default.
- NCIT_C116866 isDefinedBy ncit.owl @default.
- NCIT_C116866 label "c-Met Inhibitor MK8033" @default.
- NCIT_C116866 subClassOf NCIT_C116866 @default.
- NCIT_C116866 subClassOf NCIT_C129824 @default.
- NCIT_C116866 subClassOf NCIT_C129825 @default.
- NCIT_C116866 subClassOf NCIT_C1404 @default.
- NCIT_C116866 subClassOf NCIT_C143099 @default.
- NCIT_C116866 subClassOf NCIT_C163758 @default.
- NCIT_C116866 subClassOf NCIT_C164000 @default.
- NCIT_C116866 subClassOf NCIT_C1908 @default.
- NCIT_C116866 subClassOf NCIT_C1909 @default.
- NCIT_C116866 subClassOf NCIT_C1967 @default.
- NCIT_C116866 subClassOf NCIT_C2189 @default.
- NCIT_C116866 subClassOf NCIT_C274 @default.
- NCIT_C116866 subClassOf NCIT_C471 @default.