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- NCIT_C116870 IAO_0000115 "A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the human immunosuppressive ligand programmed death-ligand 1 (PD-L1) protein, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, avelumab binds to PD-L1 and prevents the interaction of PD-L1 with its receptor programmed cell death protein 1 (PD-1). This inhibits the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of cytotoxic T-lymphocytes (CTLs) targeted to PD-L1-overexpressing tumor cells. In addition, avelumab induces an antibody-dependent cellular cytotoxic (ADCC) response against PD-L1-expressing tumor cells. PD-1, a cell surface receptor belonging to the immunoglobulin superfamily expressed on T-cells, negatively regulates T-cell activation and effector function when activated by its ligand, and plays an important role in tumor evasion from host immunity. PD-L1, a transmembrane protein, is overexpressed on a variety of tumor cell types and is associated with poor prognosis." @default.
- NCIT_C116870 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116870 NCIT_A7 NCIT_C96024 @default.
- NCIT_C116870 NCIT_NHC0 "C116870" @default.
- NCIT_C116870 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C116870 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C116870 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116870 NCIT_P107 "Avelumab" @default.
- NCIT_C116870 NCIT_P108 "Avelumab" @default.
- NCIT_C116870 NCIT_P207 "C4055417" @default.
- NCIT_C116870 NCIT_P210 "1537032-82-8" @default.
- NCIT_C116870 NCIT_P302 "locally advanced or metastatic urothelial carcinoma; metastatic Merkel cell carcinoma (MCC); advanced renal cell carcinoma (RCC)." @default.
- NCIT_C116870 NCIT_P319 "KXG2PJ551I" @default.
- NCIT_C116870 NCIT_P322 "CTRP" @default.
- NCIT_C116870 NCIT_P322 "FDA" @default.
- NCIT_C116870 NCIT_P322 "GDC" @default.
- NCIT_C116870 NCIT_P329 "745752" @default.
- NCIT_C116870 NCIT_P330 "745752" @default.
- NCIT_C116870 NCIT_P375 "Avelumab" @default.
- NCIT_C116870 NCIT_P399 "745752" @default.
- NCIT_C116870 NCIT_R124 NCIT_C17710 @default.
- NCIT_C116870 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116870 NCIT_R124 NCIT_C18219 @default.
- NCIT_C116870 NCIT_R124 NCIT_C19986 @default.
- NCIT_C116870 NCIT_R124 NCIT_C40474 @default.
- NCIT_C116870 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C116870 referenceCount "3" @default.
- NCIT_C116870 hasExactSynonym "AVELUMAB" @default.
- NCIT_C116870 hasExactSynonym "Avelumab" @default.
- NCIT_C116870 hasExactSynonym "Bavencio" @default.
- NCIT_C116870 hasExactSynonym "Immunoglobulin G1-lambda1, Anti-(Homo sapiens CD274 (Programmed Death Ligand 1, PDL1, pd-l1, B7 Homolog 1, B7H1)), Homo sapiens Monoclonal Antibody" @default.
- NCIT_C116870 hasExactSynonym "MSB-0010718C" @default.
- NCIT_C116870 hasExactSynonym "MSB0010718C" @default.
- NCIT_C116870 inSubset NCIT_C116977 @default.
- NCIT_C116870 inSubset NCIT_C116978 @default.
- NCIT_C116870 inSubset NCIT_C128784 @default.
- NCIT_C116870 inSubset NCIT_C157711 @default.
- NCIT_C116870 inSubset NCIT_C157712 @default.
- NCIT_C116870 inSubset NCIT_C176424 @default.
- NCIT_C116870 inSubset NCIT_C177537 @default.
- NCIT_C116870 inSubset NCIT_C63923 @default.
- NCIT_C116870 type Class @default.
- NCIT_C116870 isDefinedBy ncit.owl @default.
- NCIT_C116870 label "Avelumab" @default.
- NCIT_C116870 subClassOf NCIT_C116870 @default.
- NCIT_C116870 subClassOf NCIT_C128057 @default.
- NCIT_C116870 subClassOf NCIT_C141144 @default.
- NCIT_C116870 subClassOf NCIT_C143250 @default.
- NCIT_C116870 subClassOf NCIT_C156893 @default.
- NCIT_C116870 subClassOf NCIT_C163758 @default.
- NCIT_C116870 subClassOf NCIT_C1908 @default.
- NCIT_C116870 subClassOf NCIT_C1909 @default.
- NCIT_C116870 subClassOf NCIT_C191689 @default.
- NCIT_C116870 subClassOf NCIT_C20401 @default.
- NCIT_C116870 subClassOf NCIT_C274 @default.
- NCIT_C116870 subClassOf NCIT_C307 @default.
- NCIT_C116870 subClassOf NCIT_C308 @default.