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- NCIT_C116871 IAO_0000115 "A semi-synthetic, orally bioavailable, third-generation taxane derivative and microtubule-stabilizing agent, with potential antineoplastic activity. Upon administration, simotaxel binds to tubulin, promotes microtubule assembly and stabilization, and prevents microtubule depolymerization. This results in G2/M arrest, apoptosis and the inhibition of cell proliferation in susceptible tumor cells. This agent is a poor substrate for P-glycoprotein-related drug resistance mechanisms; therefore, it may be useful for treating multi-drug resistant tumors. MST-997 is more potent than paclitaxel and docetaxel and overcomes paclitaxel and docetaxel resistance in certain tumor cell types." @default.
- NCIT_C116871 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116871 NCIT_A7 NCIT_C129655 @default.
- NCIT_C116871 NCIT_NHC0 "C116871" @default.
- NCIT_C116871 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116871 NCIT_P107 "Simotaxel" @default.
- NCIT_C116871 NCIT_P108 "Simotaxel" @default.
- NCIT_C116871 NCIT_P207 "C1541465" @default.
- NCIT_C116871 NCIT_P210 "791635-59-1" @default.
- NCIT_C116871 NCIT_P319 "E1M30YOE59" @default.
- NCIT_C116871 NCIT_P322 "CTRP" @default.
- NCIT_C116871 NCIT_P322 "FDA" @default.
- NCIT_C116871 NCIT_P322 "GDC" @default.
- NCIT_C116871 NCIT_P329 "387809" @default.
- NCIT_C116871 NCIT_P330 "387809" @default.
- NCIT_C116871 NCIT_P375 "Simotaxel" @default.
- NCIT_C116871 NCIT_P399 "387809" @default.
- NCIT_C116871 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116871 NCIT_R124 NCIT_C20480 @default.
- NCIT_C116871 NCIT_R124 NCIT_C40795 @default.
- NCIT_C116871 NCIT_R124 NCIT_C40798 @default.
- NCIT_C116871 normalizedInformationContent "100" @default.
- NCIT_C116871 referenceCount "1" @default.
- NCIT_C116871 hasExactSynonym "5Beta,20-epoxy-1,2alpa,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one-4-acetate 2-benzoate Ester with (2R,3S)-N-Isopropoxycarbonyl-3-(2-thienyl) Isoserine" @default.
- NCIT_C116871 hasExactSynonym "MST-997" @default.
- NCIT_C116871 hasExactSynonym "SIMOTAXEL" @default.
- NCIT_C116871 hasExactSynonym "Simotaxel" @default.
- NCIT_C116871 hasExactSynonym "TL-909" @default.
- NCIT_C116871 hasExactSynonym "Taxane-997" @default.
- NCIT_C116871 inSubset NCIT_C116977 @default.
- NCIT_C116871 inSubset NCIT_C116978 @default.
- NCIT_C116871 inSubset NCIT_C128784 @default.
- NCIT_C116871 inSubset NCIT_C157711 @default.
- NCIT_C116871 inSubset NCIT_C157712 @default.
- NCIT_C116871 inSubset NCIT_C176424 @default.
- NCIT_C116871 inSubset NCIT_C177537 @default.
- NCIT_C116871 inSubset NCIT_C63923 @default.
- NCIT_C116871 type Class @default.
- NCIT_C116871 isDefinedBy ncit.owl @default.
- NCIT_C116871 label "Simotaxel" @default.
- NCIT_C116871 subClassOf NCIT_C116871 @default.
- NCIT_C116871 subClassOf NCIT_C1490 @default.
- NCIT_C116871 subClassOf NCIT_C186664 @default.
- NCIT_C116871 subClassOf NCIT_C1908 @default.
- NCIT_C116871 subClassOf NCIT_C1909 @default.
- NCIT_C116871 subClassOf NCIT_C1913 @default.
- NCIT_C116871 subClassOf NCIT_C25974 @default.
- NCIT_C116871 subClassOf NCIT_C273 @default.
- NCIT_C116871 subClassOf NCIT_C274 @default.
- NCIT_C116871 subClassOf NCIT_C552 @default.
- NCIT_C116871 subClassOf NCIT_C616 @default.
- NCIT_C116871 subClassOf NCIT_C67437 @default.
- NCIT_C116871 subClassOf NCIT_C718 @default.
- NCIT_C116871 subClassOf NCIT_C860 @default.