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- NCIT_C116873 IAO_0000115 "An orally bioavailable inhibitor of one or more signal transducer and activator of transcription (STAT) protein(s), with potential antineoplastic activity. Upon oral administration, OPB-111077 binds to and inhibits the phosphorylation of STATs. This prevents binding of STATs to DNA sequences on a variety of STAT-responsive gene promoters, which may result in the inhibition of both STAT-mediated transcription and tumor cell proliferation. STATs are constitutively activated in a variety of cancers and play a key role in tumor cell proliferation." @default.
- NCIT_C116873 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116873 NCIT_A7 NCIT_C28664 @default.
- NCIT_C116873 NCIT_NHC0 "C116873" @default.
- NCIT_C116873 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116873 NCIT_P107 "STAT Inhibitor OPB-111077" @default.
- NCIT_C116873 NCIT_P108 "STAT Inhibitor OPB-111077" @default.
- NCIT_C116873 NCIT_P208 "CL446660" @default.
- NCIT_C116873 NCIT_P322 "CTRP" @default.
- NCIT_C116873 NCIT_P322 "GDC" @default.
- NCIT_C116873 NCIT_P329 "742040" @default.
- NCIT_C116873 NCIT_P330 "742040" @default.
- NCIT_C116873 NCIT_P375 "STAT Inhibitor OPB-111077" @default.
- NCIT_C116873 NCIT_P399 "742040" @default.
- NCIT_C116873 normalizedInformationContent "100" @default.
- NCIT_C116873 referenceCount "1" @default.
- NCIT_C116873 hasExactSynonym "OPB-111077" @default.
- NCIT_C116873 hasExactSynonym "STAT Inhibitor OPB-111077" @default.
- NCIT_C116873 inSubset NCIT_C116977 @default.
- NCIT_C116873 inSubset NCIT_C116978 @default.
- NCIT_C116873 inSubset NCIT_C128784 @default.
- NCIT_C116873 inSubset NCIT_C157711 @default.
- NCIT_C116873 inSubset NCIT_C157712 @default.
- NCIT_C116873 inSubset NCIT_C176424 @default.
- NCIT_C116873 inSubset NCIT_C177537 @default.
- NCIT_C116873 type Class @default.
- NCIT_C116873 isDefinedBy ncit.owl @default.
- NCIT_C116873 label "STAT Inhibitor OPB-111077" @default.
- NCIT_C116873 subClassOf NCIT_C116873 @default.
- NCIT_C116873 subClassOf NCIT_C1908 @default.
- NCIT_C116873 subClassOf NCIT_C1909 @default.
- NCIT_C116873 subClassOf NCIT_C2189 @default.
- NCIT_C116873 subClassOf NCIT_C274 @default.