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- NCIT_C116876 IAO_0000115 "An orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity. Taselisib selectively inhibits PIK3CA and its mutant forms in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting class I PI3K alpha, this agent may be more efficacious and less toxic than pan PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and causes increased tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PIK3CA, which encodes the p110-alpha catalytic subunit of the class I PI3K, is mutated in a variety of cancer cell types and plays a key role in cancer cell growth and invasion." @default.
- NCIT_C116876 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116876 NCIT_A7 NCIT_C30168 @default.
- NCIT_C116876 NCIT_NHC0 "C116876" @default.
- NCIT_C116876 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116876 NCIT_P107 "Taselisib" @default.
- NCIT_C116876 NCIT_P108 "Taselisib" @default.
- NCIT_C116876 NCIT_P207 "C3660928" @default.
- NCIT_C116876 NCIT_P210 "1282512-48-4" @default.
- NCIT_C116876 NCIT_P319 "L08J2O299M" @default.
- NCIT_C116876 NCIT_P322 "CTRP" @default.
- NCIT_C116876 NCIT_P322 "FDA" @default.
- NCIT_C116876 NCIT_P322 "GDC" @default.
- NCIT_C116876 NCIT_P329 "695816" @default.
- NCIT_C116876 NCIT_P330 "695816" @default.
- NCIT_C116876 NCIT_P375 "Taselisib" @default.
- NCIT_C116876 NCIT_P399 "695816" @default.
- NCIT_C116876 normalizedInformationContent "100" @default.
- NCIT_C116876 referenceCount "1" @default.
- NCIT_C116876 hasExactSynonym "GDC-0032" @default.
- NCIT_C116876 hasExactSynonym "RO5537381" @default.
- NCIT_C116876 hasExactSynonym "TASELISIB" @default.
- NCIT_C116876 hasExactSynonym "Taselisib" @default.
- NCIT_C116876 inSubset NCIT_C116977 @default.
- NCIT_C116876 inSubset NCIT_C116978 @default.
- NCIT_C116876 inSubset NCIT_C128784 @default.
- NCIT_C116876 inSubset NCIT_C157711 @default.
- NCIT_C116876 inSubset NCIT_C157712 @default.
- NCIT_C116876 inSubset NCIT_C176424 @default.
- NCIT_C116876 inSubset NCIT_C177537 @default.
- NCIT_C116876 inSubset NCIT_C63923 @default.
- NCIT_C116876 type Class @default.
- NCIT_C116876 isDefinedBy ncit.owl @default.
- NCIT_C116876 label "Taselisib" @default.
- NCIT_C116876 subClassOf NCIT_C116876 @default.
- NCIT_C116876 subClassOf NCIT_C129824 @default.
- NCIT_C116876 subClassOf NCIT_C129825 @default.
- NCIT_C116876 subClassOf NCIT_C1404 @default.
- NCIT_C116876 subClassOf NCIT_C163758 @default.
- NCIT_C116876 subClassOf NCIT_C1742 @default.
- NCIT_C116876 subClassOf NCIT_C1908 @default.
- NCIT_C116876 subClassOf NCIT_C1909 @default.
- NCIT_C116876 subClassOf NCIT_C2152 @default.
- NCIT_C116876 subClassOf NCIT_C2189 @default.
- NCIT_C116876 subClassOf NCIT_C274 @default.
- NCIT_C116876 subClassOf NCIT_C471 @default.