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- NCIT_C116882 IAO_0000115 "An orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor SAR260301 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in apoptosis and growth inhibition in PI3K beta-expressing and/or phosphatase and tensin homolog (PTEN)-deficient tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and contributes to increased tumor cell growth, tumor cell survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan-PI3K inhibitors." @default.
- NCIT_C116882 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116882 NCIT_A7 NCIT_C30170 @default.
- NCIT_C116882 NCIT_NHC0 "C116882" @default.
- NCIT_C116882 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116882 NCIT_P107 "PI3K-beta Inhibitor SAR260301" @default.
- NCIT_C116882 NCIT_P108 "PI3K-beta Inhibitor SAR260301" @default.
- NCIT_C116882 NCIT_P207 "C3852556" @default.
- NCIT_C116882 NCIT_P210 "1260612-13-2" @default.
- NCIT_C116882 NCIT_P319 "33639WNC7Q" @default.
- NCIT_C116882 NCIT_P322 "CTRP" @default.
- NCIT_C116882 NCIT_P322 "FDA" @default.
- NCIT_C116882 NCIT_P322 "GDC" @default.
- NCIT_C116882 NCIT_P329 "739784" @default.
- NCIT_C116882 NCIT_P330 "739784" @default.
- NCIT_C116882 NCIT_P375 "PI3K-beta Inhibitor SAR260301" @default.
- NCIT_C116882 NCIT_P399 "739784" @default.
- NCIT_C116882 normalizedInformationContent "100" @default.
- NCIT_C116882 referenceCount "1" @default.
- NCIT_C116882 hasExactSynonym "(S)-2-(2-(2-Methylindolin-1-yl)-2-oxoethyl)-6-morpholinopyrimidin-4(3H)-one" @default.
- NCIT_C116882 hasExactSynonym "PI3K-beta Inhibitor SAR260301" @default.
- NCIT_C116882 hasExactSynonym "SAR 260301" @default.
- NCIT_C116882 hasExactSynonym "SAR-260301" @default.
- NCIT_C116882 hasExactSynonym "SAR260301" @default.
- NCIT_C116882 inSubset NCIT_C116977 @default.
- NCIT_C116882 inSubset NCIT_C116978 @default.
- NCIT_C116882 inSubset NCIT_C128784 @default.
- NCIT_C116882 inSubset NCIT_C157711 @default.
- NCIT_C116882 inSubset NCIT_C157712 @default.
- NCIT_C116882 inSubset NCIT_C176424 @default.
- NCIT_C116882 inSubset NCIT_C177537 @default.
- NCIT_C116882 inSubset NCIT_C63923 @default.
- NCIT_C116882 type Class @default.
- NCIT_C116882 isDefinedBy ncit.owl @default.
- NCIT_C116882 label "PI3K-beta Inhibitor SAR260301" @default.
- NCIT_C116882 subClassOf NCIT_C116882 @default.
- NCIT_C116882 subClassOf NCIT_C129824 @default.
- NCIT_C116882 subClassOf NCIT_C129825 @default.
- NCIT_C116882 subClassOf NCIT_C1404 @default.
- NCIT_C116882 subClassOf NCIT_C163758 @default.
- NCIT_C116882 subClassOf NCIT_C1742 @default.
- NCIT_C116882 subClassOf NCIT_C1908 @default.
- NCIT_C116882 subClassOf NCIT_C1909 @default.
- NCIT_C116882 subClassOf NCIT_C2152 @default.
- NCIT_C116882 subClassOf NCIT_C2189 @default.
- NCIT_C116882 subClassOf NCIT_C274 @default.
- NCIT_C116882 subClassOf NCIT_C471 @default.