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- NCIT_C116886 IAO_0000115 "An agonistic tetravalent nanobody, in which the four single, high affinity heavy chain variable domain (VHH) antibodies are separated by a peptide linker, targeting death receptor type 5 (DR5), with potential antineoplastic activity. Upon administration, DR5-targeting tetrameric nanobody agonist TAS266, with its four DR5-specific single-chain antibodies, specifically binds to and activates DR5 receptors. This results in the activation of caspase cascades and induction of apoptosis in DR5-expressing tumor cells. DR5, a cell surface receptor and member of the tumor necrosis factor (TNF)-receptor superfamily, triggers apoptosis. Compared to certain anti-DR5 antibody agonists, TAS266 shows increased receptor activation." @default.
- NCIT_C116886 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116886 NCIT_A7 NCIT_C18178 @default.
- NCIT_C116886 NCIT_NHC0 "C116886" @default.
- NCIT_C116886 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116886 NCIT_P107 "DR5-targeting Tetrameric Nanobody Agonist TAS266" @default.
- NCIT_C116886 NCIT_P108 "DR5-targeting Tetrameric Nanobody Agonist TAS266" @default.
- NCIT_C116886 NCIT_P208 "CL433974" @default.
- NCIT_C116886 NCIT_P319 "2ND8DG76YE" @default.
- NCIT_C116886 NCIT_P322 "CTRP" @default.
- NCIT_C116886 NCIT_P322 "FDA" @default.
- NCIT_C116886 NCIT_P322 "GDC" @default.
- NCIT_C116886 NCIT_P329 "725486" @default.
- NCIT_C116886 NCIT_P330 "725486" @default.
- NCIT_C116886 NCIT_P375 "DR5-targeting Tetrameric Nanobody Agonist TAS266" @default.
- NCIT_C116886 NCIT_P399 "725486" @default.
- NCIT_C116886 normalizedInformationContent "100" @default.
- NCIT_C116886 referenceCount "1" @default.
- NCIT_C116886 hasExactSynonym "DR5-targeting Tetrameric Nanobody Agonist TAS266" @default.
- NCIT_C116886 hasExactSynonym "TAS-266" @default.
- NCIT_C116886 hasExactSynonym "TAS266" @default.
- NCIT_C116886 hasExactSynonym "Tetrameric Nanobody Agonist-targeting death receptor 5 TAS266" @default.
- NCIT_C116886 inSubset NCIT_C116977 @default.
- NCIT_C116886 inSubset NCIT_C116978 @default.
- NCIT_C116886 inSubset NCIT_C128784 @default.
- NCIT_C116886 inSubset NCIT_C157711 @default.
- NCIT_C116886 inSubset NCIT_C157712 @default.
- NCIT_C116886 inSubset NCIT_C176424 @default.
- NCIT_C116886 inSubset NCIT_C177537 @default.
- NCIT_C116886 inSubset NCIT_C63923 @default.
- NCIT_C116886 type Class @default.
- NCIT_C116886 isDefinedBy ncit.owl @default.
- NCIT_C116886 label "DR5-targeting Tetrameric Nanobody Agonist TAS266" @default.
- NCIT_C116886 subClassOf NCIT_C116886 @default.
- NCIT_C116886 subClassOf NCIT_C1908 @default.
- NCIT_C116886 subClassOf NCIT_C1909 @default.
- NCIT_C116886 subClassOf NCIT_C307 @default.