Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C116890> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- NCIT_C116890 IAO_0000115 "A nanoparticle albumin-bound formulation of a thiocolchicine dimer, an inhibitor of both microtubule and topoisomerase I (TOP1), with antineoplastic and vascular disrupting activities. Upon administration of nanoparticle albumin-bound thiocolchicine dimer nab-5404, this agent binds to tubulin and inhibits its polymerization, which blocks mitotic spindle formation and leads to cell cycle arrest and tumor endothelial cell apoptosis. This disrupts the tumor vasculature and leads to tumor necrosis. In addition, nab-5404 binds to topoisomerase I (TOPI) and inhibits its activity. This results in the inhibition of the repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. The nanoparticle albumin-based formulation permits the albumin-mediated endocytosis of the thiocolchicine dimer by tumor cells and endothelial cells." @default.
- NCIT_C116890 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116890 NCIT_NHC0 "C116890" @default.
- NCIT_C116890 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116890 NCIT_P107 "Nanoparticle Albumin-bound Thiocolchicine Dimer nab-5404" @default.
- NCIT_C116890 NCIT_P108 "Nanoparticle Albumin-bound Thiocolchicine Dimer nab-5404" @default.
- NCIT_C116890 NCIT_P208 "CL421664" @default.
- NCIT_C116890 NCIT_P210 "361169-05-3" @default.
- NCIT_C116890 NCIT_P319 "5C3JG9RQU3" @default.
- NCIT_C116890 NCIT_P322 "CTRP" @default.
- NCIT_C116890 NCIT_P322 "FDA" @default.
- NCIT_C116890 NCIT_P322 "GDC" @default.
- NCIT_C116890 NCIT_P329 "682217" @default.
- NCIT_C116890 NCIT_P330 "682217" @default.
- NCIT_C116890 NCIT_P375 "Nanoparticle Albumin-bound Thiocolchicine Dimer nab-5404" @default.
- NCIT_C116890 NCIT_P399 "682217" @default.
- NCIT_C116890 normalizedInformationContent "100" @default.
- NCIT_C116890 referenceCount "1" @default.
- NCIT_C116890 hasExactSynonym "ABI-011" @default.
- NCIT_C116890 hasExactSynonym "IDN 5404" @default.
- NCIT_C116890 hasExactSynonym "IDN-5404" @default.
- NCIT_C116890 hasExactSynonym "NTB-011" @default.
- NCIT_C116890 hasExactSynonym "Nanoparticle Albumin-bound Thiocolchicine Dimer nab-5404" @default.
- NCIT_C116890 hasExactSynonym "nab-5404" @default.
- NCIT_C116890 hasExactSynonym "nab-Thiocolchicine Dimer" @default.
- NCIT_C116890 inSubset NCIT_C116977 @default.
- NCIT_C116890 inSubset NCIT_C116978 @default.
- NCIT_C116890 inSubset NCIT_C128784 @default.
- NCIT_C116890 inSubset NCIT_C157711 @default.
- NCIT_C116890 inSubset NCIT_C157712 @default.
- NCIT_C116890 inSubset NCIT_C176424 @default.
- NCIT_C116890 inSubset NCIT_C177537 @default.
- NCIT_C116890 inSubset NCIT_C63923 @default.
- NCIT_C116890 type Class @default.
- NCIT_C116890 isDefinedBy ncit.owl @default.
- NCIT_C116890 label "Nanoparticle Albumin-bound Thiocolchicine Dimer nab-5404" @default.
- NCIT_C116890 subClassOf NCIT_C116890 @default.
- NCIT_C116890 subClassOf NCIT_C129824 @default.
- NCIT_C116890 subClassOf NCIT_C129825 @default.
- NCIT_C116890 subClassOf NCIT_C1748 @default.
- NCIT_C116890 subClassOf NCIT_C1904 @default.
- NCIT_C116890 subClassOf NCIT_C1908 @default.
- NCIT_C116890 subClassOf NCIT_C1909 @default.
- NCIT_C116890 subClassOf NCIT_C2189 @default.
- NCIT_C116890 subClassOf NCIT_C274 @default.
- NCIT_C116890 subClassOf NCIT_C471 @default.