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- NCIT_C116894 IAO_0000115 "A small molecule inhibitor of numerous tyrosine kinases (TKs) including fibroblast growth factor receptor (FGFR), vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), FMS-related tyrosine kinase 3 (FLT3), and SRC, with potential antineoplastic activity. Upon administration, XL999 binds to and inhibits the activity of these TKs, thereby preventing both the activation of downstream signaling pathways and the proliferation of tumor cells overexpressing these TKs. FGFR, VEGFR, PDGFR, FLT-3, and SRC are upregulated in a variety of cancer cell types and play key roles in tumor cell proliferation, angiogenesis, and metastasis." @default.
- NCIT_C116894 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116894 NCIT_A7 NCIT_C17297 @default.
- NCIT_C116894 NCIT_NHC0 "C116894" @default.
- NCIT_C116894 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116894 NCIT_P107 "FGFR/VEGFR/PDGFR/FLT3/SRC Inhibitor XL999" @default.
- NCIT_C116894 NCIT_P108 "FGFR/VEGFR/PDGFR/FLT3/SRC Inhibitor XL999" @default.
- NCIT_C116894 NCIT_P207 "C1541529" @default.
- NCIT_C116894 NCIT_P210 "705946-27-6" @default.
- NCIT_C116894 NCIT_P319 "6I7PLF6N8L" @default.
- NCIT_C116894 NCIT_P322 "CTRP" @default.
- NCIT_C116894 NCIT_P322 "FDA" @default.
- NCIT_C116894 NCIT_P322 "GDC" @default.
- NCIT_C116894 NCIT_P329 "425377" @default.
- NCIT_C116894 NCIT_P330 "425377" @default.
- NCIT_C116894 NCIT_P375 "FGFR/VEGFR/PDGFR/FLT3/SRC Inhibitor XL999" @default.
- NCIT_C116894 NCIT_P399 "425377" @default.
- NCIT_C116894 normalizedInformationContent "100" @default.
- NCIT_C116894 referenceCount "1" @default.
- NCIT_C116894 hasExactSynonym "FGFR/VEGFR/PDGFR/FLT3/SRC Inhibitor XL999" @default.
- NCIT_C116894 hasExactSynonym "SSKI XL999" @default.
- NCIT_C116894 hasExactSynonym "Spectrum Selective Kinase Inhibitor XL999" @default.
- NCIT_C116894 hasExactSynonym "XL-999" @default.
- NCIT_C116894 hasExactSynonym "XL999" @default.
- NCIT_C116894 inSubset NCIT_C116977 @default.
- NCIT_C116894 inSubset NCIT_C116978 @default.
- NCIT_C116894 inSubset NCIT_C128784 @default.
- NCIT_C116894 inSubset NCIT_C157711 @default.
- NCIT_C116894 inSubset NCIT_C157712 @default.
- NCIT_C116894 inSubset NCIT_C176424 @default.
- NCIT_C116894 inSubset NCIT_C177537 @default.
- NCIT_C116894 inSubset NCIT_C63923 @default.
- NCIT_C116894 type Class @default.
- NCIT_C116894 isDefinedBy ncit.owl @default.
- NCIT_C116894 label "FGFR/VEGFR/PDGFR/FLT3/SRC Inhibitor XL999" @default.
- NCIT_C116894 subClassOf NCIT_C116894 @default.
- NCIT_C116894 subClassOf NCIT_C124800 @default.
- NCIT_C116894 subClassOf NCIT_C129824 @default.
- NCIT_C116894 subClassOf NCIT_C129825 @default.
- NCIT_C116894 subClassOf NCIT_C1404 @default.
- NCIT_C116894 subClassOf NCIT_C155727 @default.
- NCIT_C116894 subClassOf NCIT_C159199 @default.
- NCIT_C116894 subClassOf NCIT_C163758 @default.
- NCIT_C116894 subClassOf NCIT_C163790 @default.
- NCIT_C116894 subClassOf NCIT_C163953 @default.
- NCIT_C116894 subClassOf NCIT_C164035 @default.
- NCIT_C116894 subClassOf NCIT_C164037 @default.
- NCIT_C116894 subClassOf NCIT_C1742 @default.
- NCIT_C116894 subClassOf NCIT_C1908 @default.
- NCIT_C116894 subClassOf NCIT_C1909 @default.
- NCIT_C116894 subClassOf NCIT_C1967 @default.
- NCIT_C116894 subClassOf NCIT_C2189 @default.
- NCIT_C116894 subClassOf NCIT_C274 @default.
- NCIT_C116894 subClassOf NCIT_C471 @default.
- NCIT_C116894 subClassOf NCIT_C93259 @default.