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- NCIT_C116914 IAO_0000115 "A preparation of genetically modified CD8+ central memory (Tcm) and CD4+ autologous T-lymphocytes (1:1) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-CD19 single chain variable fragment (scFv) derived from the murine IgG1 monoclonal antibody (mAb) FMC63, fused to the signaling domain of 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T lymphocytes are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity." @default.
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- NCIT_C116914 NCIT_NHC0 "C116914" @default.
- NCIT_C116914 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116914 NCIT_P107 "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C116914 NCIT_P108 "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C116914 NCIT_P208 "CL473980" @default.
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- NCIT_C116914 normalizedInformationContent "100" @default.
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- NCIT_C116914 hasExactSynonym "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C116914 inSubset NCIT_C116977 @default.
- NCIT_C116914 inSubset NCIT_C116978 @default.
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- NCIT_C116914 type Class @default.
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- NCIT_C116914 label "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C116914 subClassOf NCIT_C116914 @default.
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