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- NCIT_C116928 IAO_0000115 "A topical cream containing the synthetic glucocorticoid fluocinonide, with anti-inflammatory and antipruritic activities. Upon administration of the fluocinonide cream to the affected area(s), fluocinonide binds to the cytosolic glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements (GREs), which increases the expression of specific target genes, such as lipocortin-1 (annexin A1). The induction of lipocortin-1 expression by fluocinonide leads to an increased interaction and inhibition of cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins and leukotrienes. This may relieve symptoms associated with skin inflammation." @default.
- NCIT_C116928 NCIT_NHC0 "C116928" @default.
- NCIT_C116928 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116928 NCIT_P107 "Fluocinonide Cream" @default.
- NCIT_C116928 NCIT_P108 "Fluocinonide Cream" @default.
- NCIT_C116928 NCIT_P207 "C3899112" @default.
- NCIT_C116928 NCIT_P322 "CTRP" @default.
- NCIT_C116928 NCIT_P329 "700426" @default.
- NCIT_C116928 NCIT_P330 "700426" @default.
- NCIT_C116928 NCIT_P399 "700426" @default.
- NCIT_C116928 NCIT_R122 NCIT_C16484 @default.
- NCIT_C116928 NCIT_R122 NCIT_C16486 @default.
- NCIT_C116928 NCIT_R122 NCIT_C16554 @default.
- NCIT_C116928 NCIT_R122 NCIT_C16865 @default.
- NCIT_C116928 NCIT_R122 NCIT_C16946 @default.
- NCIT_C116928 NCIT_R122 NCIT_C17021 @default.
- NCIT_C116928 NCIT_R122 NCIT_C17573 @default.
- NCIT_C116928 NCIT_R122 NCIT_C20027 @default.
- NCIT_C116928 NCIT_R122 NCIT_C26548 @default.
- NCIT_C116928 NCIT_R122 NCIT_C28459 @default.
- NCIT_C116928 normalizedInformationContent "100" @default.
- NCIT_C116928 referenceCount "1" @default.
- NCIT_C116928 hasExactSynonym "Fluocinonide Cream" @default.
- NCIT_C116928 inSubset NCIT_C116977 @default.
- NCIT_C116928 inSubset NCIT_C116978 @default.
- NCIT_C116928 inSubset NCIT_C176424 @default.
- NCIT_C116928 type Class @default.
- NCIT_C116928 isDefinedBy ncit.owl @default.
- NCIT_C116928 label "Fluocinonide Cream" @default.
- NCIT_C116928 subClassOf NCIT_C116928 @default.
- NCIT_C116928 subClassOf NCIT_C147908 @default.
- NCIT_C116928 subClassOf NCIT_C1636 @default.
- NCIT_C116928 subClassOf NCIT_C1908 @default.
- NCIT_C116928 subClassOf NCIT_C1909 @default.
- NCIT_C116928 subClassOf NCIT_C211 @default.
- NCIT_C116928 subClassOf NCIT_C2364 @default.
- NCIT_C116928 subClassOf NCIT_C308 @default.
- NCIT_C116928 subClassOf NCIT_C521 @default.
- NCIT_C116928 subClassOf NCIT_C548 @default.
- NCIT_C116928 subClassOf NCIT_C574 @default.