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- NCIT_C117229 IAO_0000115 "An immunoconjugate consisting of anti-carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) conjugated to a cytotoxic agent, with potential antineoplastic activity. Upon administration of tusamitamab ravtansine the antibody moiety targets CEACAM5 on tumor cells. Upon antibody/antigen binding and internalization, the immunoconjugate releases the cytotoxic agent, which results in tumor cell death. CEACAM5, a member of the CEA family of proteins that plays a key role in cell migration, cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types." @default.
- NCIT_C117229 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117229 NCIT_A7 NCIT_C16384 @default.
- NCIT_C117229 NCIT_NHC0 "C117229" @default.
- NCIT_C117229 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117229 NCIT_P107 "Anti-5T4 Antibody-Drug Conjugate PF-06263507" @default.
- NCIT_C117229 NCIT_P107 "Tusamitamab Ravtansine" @default.
- NCIT_C117229 NCIT_P108 "Tusamitamab Ravtansine" @default.
- NCIT_C117229 NCIT_P208 "CL474097" @default.
- NCIT_C117229 NCIT_P210 "2254086-60-5" @default.
- NCIT_C117229 NCIT_P319 "DSS3BE2ZXN" @default.
- NCIT_C117229 NCIT_P322 "CTRP" @default.
- NCIT_C117229 NCIT_P322 "FDA" @default.
- NCIT_C117229 NCIT_P322 "GDC" @default.
- NCIT_C117229 NCIT_P329 "762948" @default.
- NCIT_C117229 NCIT_P330 "762948" @default.
- NCIT_C117229 NCIT_P375 "Anti-CEACAM5 Antibody-Drug Conjugate SAR408701" @default.
- NCIT_C117229 NCIT_P399 "762948" @default.
- NCIT_C117229 normalizedInformationContent "100" @default.
- NCIT_C117229 referenceCount "1" @default.
- NCIT_C117229 hasExactSynonym "ADC SAR408701" @default.
- NCIT_C117229 hasExactSynonym "Anti-CEACAM5 Antibody-Drug Conjugate SAR408701" @default.
- NCIT_C117229 hasExactSynonym "SAR408701" @default.
- NCIT_C117229 hasExactSynonym "TUSAMITAMAB RAVTANSINE" @default.
- NCIT_C117229 hasExactSynonym "Tusamitamab Ravtansine" @default.
- NCIT_C117229 inSubset NCIT_C116977 @default.
- NCIT_C117229 inSubset NCIT_C116978 @default.
- NCIT_C117229 inSubset NCIT_C128784 @default.
- NCIT_C117229 inSubset NCIT_C157711 @default.
- NCIT_C117229 inSubset NCIT_C157712 @default.
- NCIT_C117229 inSubset NCIT_C176424 @default.
- NCIT_C117229 inSubset NCIT_C177537 @default.
- NCIT_C117229 inSubset NCIT_C63923 @default.
- NCIT_C117229 type Class @default.
- NCIT_C117229 isDefinedBy ncit.owl @default.
- NCIT_C117229 label "Tusamitamab Ravtansine" @default.
- NCIT_C117229 subClassOf NCIT_C117229 @default.
- NCIT_C117229 subClassOf NCIT_C129821 @default.
- NCIT_C117229 subClassOf NCIT_C129823 @default.
- NCIT_C117229 subClassOf NCIT_C1512 @default.
- NCIT_C117229 subClassOf NCIT_C163758 @default.
- NCIT_C117229 subClassOf NCIT_C1908 @default.
- NCIT_C117229 subClassOf NCIT_C1909 @default.
- NCIT_C117229 subClassOf NCIT_C200043 @default.
- NCIT_C117229 subClassOf NCIT_C201549 @default.
- NCIT_C117229 subClassOf NCIT_C274 @default.
- NCIT_C117229 subClassOf NCIT_C307 @default.
- NCIT_C117229 subClassOf NCIT_C308 @default.