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- NCIT_C117231 IAO_0000115 "A proprietary, human cytotoxic cell line composed of allogeneic, activated, interleukin-2 (IL-2) dependent-natural killer cells derived from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma, with potential antineoplastic activity. As NK-92 cells are devoid of killer inhibitory receptors (KIRs; also called killer cell immunoglobulin-like receptors), which are negative regulators of NK cell activity, cancer cells are unable to suppress the cancer cell killing ability of the NK-92 cells. Upon infusion of the allogeneic NK cell line NK-92, the NKs recognize and bind to tumor cells. This leads to the secretion and release of perforins, granzymes, cytokines and chemokines, which results in cancer cell lysis and apoptosis. In addition, NK-92 cells express high affinity Fc receptors, which bind to therapeutic antibodies; therefore, this agent can enhance antibody dependent cellular cytotoxicity (ADCC) of co-administered therapeutic antibodies." @default.
- NCIT_C117231 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117231 NCIT_NHC0 "C117231" @default.
- NCIT_C117231 NCIT_P106 "Cell" @default.
- NCIT_C117231 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117231 NCIT_P107 "Allogeneic Natural Killer Cell Line NK-92" @default.
- NCIT_C117231 NCIT_P108 "Allogeneic Natural Killer Cell Line NK-92" @default.
- NCIT_C117231 NCIT_P208 "CL474099" @default.
- NCIT_C117231 NCIT_P319 "Y0EW4890B4" @default.
- NCIT_C117231 NCIT_P322 "CTRP" @default.
- NCIT_C117231 NCIT_P322 "FDA" @default.
- NCIT_C117231 NCIT_P322 "GDC" @default.
- NCIT_C117231 NCIT_P329 "763083" @default.
- NCIT_C117231 NCIT_P330 "763083" @default.
- NCIT_C117231 NCIT_P375 "Allogeneic Natural Killer Cell Line NK-92" @default.
- NCIT_C117231 NCIT_P399 "763083" @default.
- NCIT_C117231 normalizedInformationContent "100" @default.
- NCIT_C117231 referenceCount "1" @default.
- NCIT_C117231 hasExactSynonym "Allogeneic Natural Killer Cell Line NK-92" @default.
- NCIT_C117231 hasExactSynonym "HUMAN NATURAL KILLER CELL LINE NK-92" @default.
- NCIT_C117231 hasExactSynonym "NK-92 Cells" @default.
- NCIT_C117231 hasExactSynonym "NK-92" @default.
- NCIT_C117231 hasExactSynonym "haNK" @default.
- NCIT_C117231 inSubset NCIT_C116977 @default.
- NCIT_C117231 inSubset NCIT_C116978 @default.
- NCIT_C117231 inSubset NCIT_C128784 @default.
- NCIT_C117231 inSubset NCIT_C157711 @default.
- NCIT_C117231 inSubset NCIT_C157712 @default.
- NCIT_C117231 inSubset NCIT_C176424 @default.
- NCIT_C117231 inSubset NCIT_C177537 @default.
- NCIT_C117231 inSubset NCIT_C63923 @default.
- NCIT_C117231 type Class @default.
- NCIT_C117231 isDefinedBy ncit.owl @default.
- NCIT_C117231 label "Allogeneic Natural Killer Cell Line NK-92" @default.
- NCIT_C117231 subClassOf NCIT_C117231 @default.
- NCIT_C117231 subClassOf NCIT_C129820 @default.
- NCIT_C117231 subClassOf NCIT_C129821 @default.
- NCIT_C117231 subClassOf NCIT_C129826 @default.
- NCIT_C117231 subClassOf NCIT_C142078 @default.
- NCIT_C117231 subClassOf NCIT_C1908 @default.
- NCIT_C117231 subClassOf NCIT_C1909 @default.
- NCIT_C117231 subClassOf NCIT_C201545 @default.
- NCIT_C117231 subClassOf NCIT_C274 @default.
- NCIT_C117231 subClassOf NCIT_C28676 @default.
- NCIT_C117231 subClassOf NCIT_C307 @default.
- NCIT_C117231 subClassOf NCIT_C308 @default.