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- NCIT_C117232 IAO_0000115 "Third generation, chimeric antigen receptor (CAR) cells composed of T-lymphocytes transduced with a lentiviral vector expressing a CAR consisting of an a single chain variable fragment specific for a particular antigen, coupled to the two co-stimulatory signaling domains Cluster of Differentiation 28 (CD28) and Cluster of Differentiation 137 (CD137; 4-1BB), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD28CAR/CD137CAR-expressing T-lymphocytes are directed to, and induce selective toxicity in tumor cells expressing the particular antigen. CD28, a T-cell surface-associated co-stimulatory molecule, is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of the antigen. Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity when compared to the inclusion of the CD28 co-stimulatory domain and CD3-zeta alone." @default.
- NCIT_C117232 NCIT_NHC0 "C117232" @default.
- NCIT_C117232 NCIT_P106 "Cell" @default.
- NCIT_C117232 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117232 NCIT_P108 "CD28CAR/CD137CAR-expressing T-Lymphocytes" @default.
- NCIT_C117232 NCIT_P208 "CL474100" @default.
- NCIT_C117232 NCIT_P329 "763099" @default.
- NCIT_C117232 NCIT_P330 "763099" @default.
- NCIT_C117232 NCIT_P399 "763099" @default.
- NCIT_C117232 normalizedInformationContent "100" @default.
- NCIT_C117232 referenceCount "1" @default.
- NCIT_C117232 hasExactSynonym "CD28CAR/CD137CAR-expressing T-Lymphocytes" @default.
- NCIT_C117232 inSubset NCIT_C128784 @default.
- NCIT_C117232 inSubset NCIT_C176424 @default.
- NCIT_C117232 type Class @default.
- NCIT_C117232 isDefinedBy ncit.owl @default.
- NCIT_C117232 label "CD28CAR/CD137CAR-expressing T-Lymphocytes" @default.
- NCIT_C117232 subClassOf NCIT_C117232 @default.
- NCIT_C117232 subClassOf NCIT_C129820 @default.
- NCIT_C117232 subClassOf NCIT_C129821 @default.
- NCIT_C117232 subClassOf NCIT_C129826 @default.
- NCIT_C117232 subClassOf NCIT_C137999 @default.
- NCIT_C117232 subClassOf NCIT_C142078 @default.
- NCIT_C117232 subClassOf NCIT_C154231 @default.
- NCIT_C117232 subClassOf NCIT_C1908 @default.
- NCIT_C117232 subClassOf NCIT_C1909 @default.
- NCIT_C117232 subClassOf NCIT_C1962 @default.
- NCIT_C117232 subClassOf NCIT_C274 @default.
- NCIT_C117232 subClassOf NCIT_C307 @default.
- NCIT_C117232 subClassOf NCIT_C308 @default.