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- NCIT_C117233 IAO_0000115 "A preparation of ex vivo expanded, genetically modified autologous central memory-enriched T-cells (Tcm) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), and containing the cluster of differentiation 137 (CD137; 4-1BB) co-stimulatory signaling domain fused to the signaling domain of the T cell antigen receptor complex zeta chain (CD3-zeta), and a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating and antineoplastic activities. Upon intratumoral or intracavitary administration, IL13Ra2-specific, hinge-optimized, 41BB-co-stimulatory CAR/truncated CD19 expressing T-lymphocytes are directed to, and induce selective toxicity and cytolysis in IL13Ra2-expressing tumor cells. IL13Ra2, overexpressed by a variety of tumor cell types, is associated with increased tumor cell proliferation, migration and invasiveness. The costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents the recognition and clearance of the CAR by endogenous Fc receptors (FcRs). CD19t is used as a surface marker to both quantify and track the gene modified T-cells in vivo." @default.
- NCIT_C117233 NCIT_NHC0 "C117233" @default.
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- NCIT_C117233 NCIT_P108 "IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes" @default.
- NCIT_C117233 NCIT_P208 "CL474101" @default.
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- NCIT_C117233 hasExactSynonym "Autologous IL13(EQ)BBzeta/CD19t+ TCM-enriched T Cells" @default.
- NCIT_C117233 hasExactSynonym "IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes" @default.
- NCIT_C117233 inSubset NCIT_C128784 @default.
- NCIT_C117233 inSubset NCIT_C176424 @default.
- NCIT_C117233 type Class @default.
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- NCIT_C117233 label "IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes" @default.
- NCIT_C117233 subClassOf NCIT_C117233 @default.
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