Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C117238> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- NCIT_C117238 IAO_0000115 "An anti-CD123/anti-CD3 bispecific humanized monoclonal antibody with potential immunostimulatory and antineoplastic activities. Flotetuzumab possesses two antigen-recognition and binding sites, one for the CD3 complex, a group of T-cell surface glycoproteins that complex with the T-cell receptor (TCR), and one for CD123, a tumor-associated antigen (TAA) overexpressed on the surface of certain tumor cells. Upon administration of flotetuzumab, this bispecific antibody simultaneously binds to both CD3-expressing T-cells and CD123-expressing cancer cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This may result in potent CTL-mediated cell lysis of CD123-expressing tumor cells. CD123, the interleukin-3 receptor alpha chain, is overexpressed in a variety of hematological malignancies; its expression is low or absent in normal hematopoietic progenitors and stem cells." @default.
- NCIT_C117238 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117238 NCIT_NHC0 "C117238" @default.
- NCIT_C117238 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C117238 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117238 NCIT_P107 "Flotetuzumab" @default.
- NCIT_C117238 NCIT_P108 "Flotetuzumab" @default.
- NCIT_C117238 NCIT_P208 "CL474112" @default.
- NCIT_C117238 NCIT_P210 "1664355-28-5" @default.
- NCIT_C117238 NCIT_P319 "0AHT0IC02G" @default.
- NCIT_C117238 NCIT_P322 "CTRP" @default.
- NCIT_C117238 NCIT_P322 "FDA" @default.
- NCIT_C117238 NCIT_P322 "GDC" @default.
- NCIT_C117238 NCIT_P329 "763236" @default.
- NCIT_C117238 NCIT_P330 "763236" @default.
- NCIT_C117238 NCIT_P375 "Flotetuzumab" @default.
- NCIT_C117238 NCIT_P399 "763236" @default.
- NCIT_C117238 NCIT_R124 NCIT_C17710 @default.
- NCIT_C117238 NCIT_R124 NCIT_C17828 @default.
- NCIT_C117238 NCIT_R124 NCIT_C18219 @default.
- NCIT_C117238 NCIT_R124 NCIT_C19986 @default.
- NCIT_C117238 NCIT_R124 NCIT_C40474 @default.
- NCIT_C117238 normalizedInformationContent "100" @default.
- NCIT_C117238 referenceCount "1" @default.
- NCIT_C117238 hasExactSynonym "CD123 x CD3 DART Bi-Specific Antibody MGD006" @default.
- NCIT_C117238 hasExactSynonym "CD123 x CD3 Dual Affinity Re-Targeting Bi-Specific Antibody MGD006" @default.
- NCIT_C117238 hasExactSynonym "FLOTETUZUMAB" @default.
- NCIT_C117238 hasExactSynonym "Flotetuzumab" @default.
- NCIT_C117238 hasExactSynonym "MGD006" @default.
- NCIT_C117238 hasExactSynonym "RES234" @default.
- NCIT_C117238 hasExactSynonym "S80880" @default.
- NCIT_C117238 inSubset NCIT_C116977 @default.
- NCIT_C117238 inSubset NCIT_C116978 @default.
- NCIT_C117238 inSubset NCIT_C128784 @default.
- NCIT_C117238 inSubset NCIT_C157711 @default.
- NCIT_C117238 inSubset NCIT_C157712 @default.
- NCIT_C117238 inSubset NCIT_C176424 @default.
- NCIT_C117238 inSubset NCIT_C177537 @default.
- NCIT_C117238 inSubset NCIT_C63923 @default.
- NCIT_C117238 type Class @default.
- NCIT_C117238 isDefinedBy ncit.owl @default.
- NCIT_C117238 label "Flotetuzumab" @default.
- NCIT_C117238 subClassOf NCIT_C112883 @default.
- NCIT_C117238 subClassOf NCIT_C117238 @default.
- NCIT_C117238 subClassOf NCIT_C129821 @default.
- NCIT_C117238 subClassOf NCIT_C129822 @default.
- NCIT_C117238 subClassOf NCIT_C1454 @default.
- NCIT_C117238 subClassOf NCIT_C1908 @default.
- NCIT_C117238 subClassOf NCIT_C1909 @default.
- NCIT_C117238 subClassOf NCIT_C201282 @default.
- NCIT_C117238 subClassOf NCIT_C20401 @default.
- NCIT_C117238 subClassOf NCIT_C274 @default.
- NCIT_C117238 subClassOf NCIT_C28227 @default.
- NCIT_C117238 subClassOf NCIT_C307 @default.
- NCIT_C117238 subClassOf NCIT_C308 @default.