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- NCIT_C117241 IAO_0000115 "A chimeric monoclonal antibody specifically targeting human immunoglobulin light chain (LC)-related fibrils, which may potentially be used in the treatment of light chain-associated (AL) amyloidosis. Upon administration, anselamimab targets and binds to the amyloid-related, conformational epitope on LC-related fibrils. This inhibits fibrillogenesis, induces an Fc-mediated cellular inflammatory response, increases degradation and elimination of AL amyloidomas, and prevents systemic LC-associated amyloid deposits. In AL amyloidosis the amyloid fibrils are composed of immunoglobulin light chain fragments." @default.
- NCIT_C117241 NCIT_NHC0 "C117241" @default.
- NCIT_C117241 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C117241 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C117241 NCIT_P108 "Anselamimab" @default.
- NCIT_C117241 NCIT_P208 "CL474109" @default.
- NCIT_C117241 NCIT_P210 "2414866-63-8" @default.
- NCIT_C117241 NCIT_P319 "TL94QQ5RTW" @default.
- NCIT_C117241 NCIT_P322 "FDA" @default.
- NCIT_C117241 NCIT_P329 "763221" @default.
- NCIT_C117241 NCIT_P330 "763221" @default.
- NCIT_C117241 NCIT_P399 "763221" @default.
- NCIT_C117241 NCIT_R124 NCIT_C17710 @default.
- NCIT_C117241 NCIT_R124 NCIT_C17828 @default.
- NCIT_C117241 NCIT_R124 NCIT_C18219 @default.
- NCIT_C117241 NCIT_R124 NCIT_C19986 @default.
- NCIT_C117241 NCIT_R124 NCIT_C40474 @default.
- NCIT_C117241 normalizedInformationContent "100" @default.
- NCIT_C117241 referenceCount "1" @default.
- NCIT_C117241 hasExactSynonym "11-1F4" @default.
- NCIT_C117241 hasExactSynonym "111F4" @default.
- NCIT_C117241 hasExactSynonym "ANSELAMIMAB" @default.
- NCIT_C117241 hasExactSynonym "Anselamimab" @default.
- NCIT_C117241 hasExactSynonym "CAEL 101" @default.
- NCIT_C117241 hasExactSynonym "CAEL-101" @default.
- NCIT_C117241 hasExactSynonym "CAEL101" @default.
- NCIT_C117241 hasExactSynonym "Chimeric Amyloid-reactive Monoclonal Antibody CAEL-101" @default.
- NCIT_C117241 hasExactSynonym "Chimeric Fibril-reactive Monoclonal Antibody CAEL-101" @default.
- NCIT_C117241 hasExactSynonym "c11-1F4 mAb" @default.
- NCIT_C117241 hasExactSynonym "mAb-11-1F4" @default.
- NCIT_C117241 inSubset NCIT_C176424 @default.
- NCIT_C117241 inSubset NCIT_C63923 @default.
- NCIT_C117241 type Class @default.
- NCIT_C117241 isDefinedBy ncit.owl @default.
- NCIT_C117241 label "Anselamimab" @default.
- NCIT_C117241 subClassOf NCIT_C117241 @default.
- NCIT_C117241 subClassOf NCIT_C1908 @default.
- NCIT_C117241 subClassOf NCIT_C1909 @default.
- NCIT_C117241 subClassOf NCIT_C20401 @default.
- NCIT_C117241 subClassOf NCIT_C307 @default.
- NCIT_C117241 subClassOf NCIT_C308 @default.