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- NCIT_C117274 IAO_0000115 "A combination preparation composed of the adrenergic beta-1 receptor antagonist atenolol and thiazide-like diuretic chlorthalidone, with anti-hypertensive activity. Atenolol selectively binds to beta-1 adrenergic receptors in the heart and vascular smooth muscle, thereby inhibiting sympathetic stimulation. This results in a decrease in cardiac rate and muscle contractility, thereby reducing cardiac output. As a diuretic, chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule (DCT) in the kidney. This leads to an increase in sodium, chloride, bicarbonate, and potassium secretion and results in the excretion of water. Together, these agents lead to a reduction in blood pressure." @default.
- NCIT_C117274 NCIT_NHC0 "C117274" @default.
- NCIT_C117274 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117274 NCIT_P108 "Atenolol/Chlorthalidone" @default.
- NCIT_C117274 NCIT_P207 "C0590743" @default.
- NCIT_C117274 normalizedInformationContent "100" @default.
- NCIT_C117274 referenceCount "1" @default.
- NCIT_C117274 hasExactSynonym "Atenolol/Chlorthalidone" @default.
- NCIT_C117274 hasExactSynonym "Tenoretic" @default.
- NCIT_C117274 type Class @default.
- NCIT_C117274 isDefinedBy ncit.owl @default.
- NCIT_C117274 label "Atenolol/Chlorthalidone" @default.
- NCIT_C117274 subClassOf NCIT_C117274 @default.
- NCIT_C117274 subClassOf NCIT_C1908 @default.
- NCIT_C117274 subClassOf NCIT_C1909 @default.
- NCIT_C117274 subClassOf NCIT_C29629 @default.
- NCIT_C117274 subClassOf NCIT_C29636 @default.