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- NCIT_C117288 IAO_0000115 "An orally bioavailable, glucoside derivative of the flavonoid quercetin and protein disulfide isomerase (PDI) inhibitor, with antioxidant and potential antithrombotic activity. As an antioxidant, isoquercetin scavenges free radicals and inhibits oxidative damage to cells. As a PDI inhibitor, this agent blocks PDI-mediated platelet activation, and fibrin generation, which prevents thrombus formation after vascular injury. In addition, isoquercetin is an alpha-glucosidase inhibitor. PDI, an oxidoreductase secreted by activated endothelial cells and platelets, plays a key role in the initiation of the coagulation cascade. Cancer, in addition to other thrombotic disorders, increases the risk of thrombus formation." @default.
- NCIT_C117288 NCIT_NHC0 "C117288" @default.
- NCIT_C117288 NCIT_P106 "Organic Chemical" @default.
- NCIT_C117288 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117288 NCIT_P107 "Quercetin" @default.
- NCIT_C117288 NCIT_P108 "Isoquercetin" @default.
- NCIT_C117288 NCIT_P208 "CL474738" @default.
- NCIT_C117288 NCIT_P210 "482-35-9" @default.
- NCIT_C117288 NCIT_P319 "6HN2PC637T" @default.
- NCIT_C117288 NCIT_P322 "FDA" @default.
- NCIT_C117288 NCIT_P329 "763386" @default.
- NCIT_C117288 NCIT_P330 "763386" @default.
- NCIT_C117288 NCIT_P399 "763386" @default.
- NCIT_C117288 normalizedInformationContent "100" @default.
- NCIT_C117288 referenceCount "1" @default.
- NCIT_C117288 hasExactSynonym "2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one" @default.
- NCIT_C117288 hasExactSynonym "IQC-950AN" @default.
- NCIT_C117288 hasExactSynonym "ISOQUERCETIN" @default.
- NCIT_C117288 hasExactSynonym "Isoquercetin" @default.
- NCIT_C117288 inSubset NCIT_C173381 @default.
- NCIT_C117288 inSubset NCIT_C173383 @default.
- NCIT_C117288 inSubset NCIT_C176424 @default.
- NCIT_C117288 inSubset NCIT_C63923 @default.
- NCIT_C117288 type Class @default.
- NCIT_C117288 isDefinedBy ncit.owl @default.
- NCIT_C117288 label "Isoquercetin" @default.
- NCIT_C117288 subClassOf NCIT_C117288 @default.
- NCIT_C117288 subClassOf NCIT_C1908 @default.
- NCIT_C117288 subClassOf NCIT_C1913 @default.
- NCIT_C117288 subClassOf NCIT_C1915 @default.
- NCIT_C117288 subClassOf NCIT_C1930 @default.
- NCIT_C117288 subClassOf NCIT_C1933 @default.
- NCIT_C117288 subClassOf NCIT_C1949 @default.
- NCIT_C117288 subClassOf NCIT_C28203 @default.
- NCIT_C117288 subClassOf NCIT_C54060 @default.
- NCIT_C117288 subClassOf NCIT_C552 @default.
- NCIT_C117288 subClassOf NCIT_C553 @default.
- NCIT_C117288 subClassOf NCIT_C68456 @default.
- NCIT_C117288 subClassOf NCIT_C70553 @default.
- NCIT_C117288 subClassOf NCIT_C70554 @default.
- NCIT_C117288 subClassOf NCIT_C718 @default.