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- NCIT_C117289 IAO_0000115 "An orally bioavailable, traditional Chinese medicine (TCM)-based formulation composed of Realgar-Indigo naturalis formula (RIF) with potential antineoplastic activity. The main constituents in RIF are realgar, Indigo naturalis, and Salvia miltiorrhiza, with tetraarsenic tetrasulfide (As4S4), indirubin and tanshinone IIA as the main active ingredients, respectively, which appear to exert synergistic effects on cancer cells. Tetraarsenic tetrasulfide specifically induces the ubiquitination and degradation of promyelocytic leukemia retinoic acid receptor alpha (PML-RARalpha) oncoprotein. In addition, the active ingredients in the Realgar-Indigo naturalis formulation enhance the expression of myeloid differentiation genes, and induce G(1)/G(0) cell cycle arrest. PML-RARalpha, an acute promyelocytic leukemia (APL)-specific fusion gene, inhibits differentiation and promotes survival of myeloid precursor cells" @default.
- NCIT_C117289 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117289 NCIT_NHC0 "C117289" @default.
- NCIT_C117289 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117289 NCIT_P108 "Realgar-Indigo naturalis Formulation" @default.
- NCIT_C117289 NCIT_P208 "CL474115" @default.
- NCIT_C117289 NCIT_P322 "GDC" @default.
- NCIT_C117289 NCIT_P329 "763399" @default.
- NCIT_C117289 NCIT_P330 "763399" @default.
- NCIT_C117289 NCIT_P375 "Realgar-Indigo naturalis Formulation" @default.
- NCIT_C117289 NCIT_P399 "763399" @default.
- NCIT_C117289 normalizedInformationContent "100" @default.
- NCIT_C117289 referenceCount "1" @default.
- NCIT_C117289 hasExactSynonym "RIF Formula" @default.
- NCIT_C117289 hasExactSynonym "RIF" @default.
- NCIT_C117289 hasExactSynonym "Realgar-Indigo naturalis Formulation" @default.
- NCIT_C117289 inSubset NCIT_C128784 @default.
- NCIT_C117289 inSubset NCIT_C157711 @default.
- NCIT_C117289 inSubset NCIT_C157712 @default.
- NCIT_C117289 inSubset NCIT_C176424 @default.
- NCIT_C117289 inSubset NCIT_C177537 @default.
- NCIT_C117289 type Class @default.
- NCIT_C117289 isDefinedBy ncit.owl @default.
- NCIT_C117289 label "Realgar-Indigo naturalis Formulation" @default.
- NCIT_C117289 subClassOf NCIT_C117289 @default.
- NCIT_C117289 subClassOf NCIT_C129986 @default.
- NCIT_C117289 subClassOf NCIT_C1907 @default.
- NCIT_C117289 subClassOf NCIT_C1908 @default.
- NCIT_C117289 subClassOf NCIT_C1909 @default.
- NCIT_C117289 subClassOf NCIT_C1931 @default.
- NCIT_C117289 subClassOf NCIT_C274 @default.
- NCIT_C117289 subClassOf NCIT_C66892 @default.