Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C117290> ?p ?o ?g. }
Showing items 1 to 37 of
37
with 100 items per page.
- NCIT_C117290 IAO_0000115 "An orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR) (mTOR complex 1; mTORC1), rictor-mTOR (mTOR complex 2; mTORC2) and dihydrofolate reductase (DHFR) with potential antineoplastic activity. Upon oral administration, mTORC1/mTORC2/DHFR inhibitor ABTL0812 binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells. mTOR is a serine/threonine kinase that is upregulated in some tumors; it plays an important role in the PI3K/Akt/mTOR signaling pathway which is often deregulated in cancer cells. In addition, ABTL0812 inhibits DHFR, an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, thereby blocking tetrahydrofolate synthesis, and resulting in both the depletion of nucleotide precursors and the inhibition of DNA, RNA and protein synthesis. This induces autophagy-induced cell death and further inhibition of cell proliferation." @default.
- NCIT_C117290 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117290 NCIT_NHC0 "C117290" @default.
- NCIT_C117290 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117290 NCIT_P108 "mTORC1/mTORC2/DHFR Inhibitor ABTL0812" @default.
- NCIT_C117290 NCIT_P208 "CL474116" @default.
- NCIT_C117290 NCIT_P210 "57818-44-7" @default.
- NCIT_C117290 NCIT_P319 "0DE74TJ7EZ" @default.
- NCIT_C117290 NCIT_P322 "FDA" @default.
- NCIT_C117290 NCIT_P322 "GDC" @default.
- NCIT_C117290 NCIT_P329 "763422" @default.
- NCIT_C117290 NCIT_P330 "763422" @default.
- NCIT_C117290 NCIT_P375 "mTORC1/mTORC2/DHFR Inhibitor ABTL0812" @default.
- NCIT_C117290 NCIT_P399 "763422" @default.
- NCIT_C117290 normalizedInformationContent "100" @default.
- NCIT_C117290 referenceCount "1" @default.
- NCIT_C117290 hasExactSynonym "9,12-Octadecadienoic Acid, 2-Hydroxy-, (9Z,12Z)-" @default.
- NCIT_C117290 hasExactSynonym "ABTL-0812" @default.
- NCIT_C117290 hasExactSynonym "ABTL0812" @default.
- NCIT_C117290 hasExactSynonym "mTORC1/mTORC2/DHFR Inhibitor ABTL0812" @default.
- NCIT_C117290 inSubset NCIT_C128784 @default.
- NCIT_C117290 inSubset NCIT_C157711 @default.
- NCIT_C117290 inSubset NCIT_C157712 @default.
- NCIT_C117290 inSubset NCIT_C176424 @default.
- NCIT_C117290 inSubset NCIT_C177537 @default.
- NCIT_C117290 inSubset NCIT_C63923 @default.
- NCIT_C117290 type Class @default.
- NCIT_C117290 isDefinedBy ncit.owl @default.
- NCIT_C117290 label "mTORC1/mTORC2/DHFR Inhibitor ABTL0812" @default.
- NCIT_C117290 subClassOf NCIT_C117290 @default.
- NCIT_C117290 subClassOf NCIT_C129824 @default.
- NCIT_C117290 subClassOf NCIT_C129825 @default.
- NCIT_C117290 subClassOf NCIT_C1908 @default.
- NCIT_C117290 subClassOf NCIT_C1909 @default.
- NCIT_C117290 subClassOf NCIT_C2189 @default.
- NCIT_C117290 subClassOf NCIT_C274 @default.
- NCIT_C117290 subClassOf NCIT_C471 @default.