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- NCIT_C117291 IAO_0000115 "An injectable, water soluble, small molecule drug conjugate (SMDC) containing a ligand specific for prostate-specific membrane antigen (PSMA), conjugated via a stable, enzyme-cleavable linker to the cytotoxic agent tubulysin B hydrazide (TubBH), with potential antineoplastic activity. Upon administration of PSMA-targeted tubulysin B-containing conjugate EC1169, the PSMA ligand specifically targets and binds to PSMA, a protein which is abundantly expressed on the surface of metastatic and hormone-refractory prostate cancer cells as well as on the neovasculature of many solid tumors. This allows for the specific delivery of TubBH to PSMA-expressing cancer cells. Upon internalization and cleavage, tubulysin B binds to tubulin and inhibits microtubule polymerization, which blocks cell division and results in G2/M phase arrest, tumor cell apoptosis and a decrease in PSMA-expressing tumor cells." @default.
- NCIT_C117291 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117291 NCIT_A7 NCIT_C17796 @default.
- NCIT_C117291 NCIT_NHC0 "C117291" @default.
- NCIT_C117291 NCIT_P106 "Chemical" @default.
- NCIT_C117291 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C117291 NCIT_P107 "PSMA-targeted Tubulysin B-containing Conjugate EC1169" @default.
- NCIT_C117291 NCIT_P108 "PSMA-targeted Tubulysin B-containing Conjugate EC1169" @default.
- NCIT_C117291 NCIT_P208 "CL474117" @default.
- NCIT_C117291 NCIT_P322 "CTRP" @default.
- NCIT_C117291 NCIT_P322 "GDC" @default.
- NCIT_C117291 NCIT_P329 "763440" @default.
- NCIT_C117291 NCIT_P330 "763440" @default.
- NCIT_C117291 NCIT_P375 "PSMA-targeted Tubulysin B-containing Conjugate EC1169" @default.
- NCIT_C117291 NCIT_P399 "763440" @default.
- NCIT_C117291 normalizedInformationContent "100" @default.
- NCIT_C117291 referenceCount "1" @default.
- NCIT_C117291 hasExactSynonym "EC1169" @default.
- NCIT_C117291 hasExactSynonym "EC1719" @default.
- NCIT_C117291 hasExactSynonym "PSMA-targeted Tubulysin B-containing Conjugate EC1169" @default.
- NCIT_C117291 inSubset NCIT_C116977 @default.
- NCIT_C117291 inSubset NCIT_C116978 @default.
- NCIT_C117291 inSubset NCIT_C128784 @default.
- NCIT_C117291 inSubset NCIT_C157711 @default.
- NCIT_C117291 inSubset NCIT_C157712 @default.
- NCIT_C117291 inSubset NCIT_C176424 @default.
- NCIT_C117291 inSubset NCIT_C177537 @default.
- NCIT_C117291 type Class @default.
- NCIT_C117291 isDefinedBy ncit.owl @default.
- NCIT_C117291 label "PSMA-targeted Tubulysin B-containing Conjugate EC1169" @default.
- NCIT_C117291 subClassOf NCIT_C117291 @default.
- NCIT_C117291 subClassOf NCIT_C1512 @default.
- NCIT_C117291 subClassOf NCIT_C163758 @default.
- NCIT_C117291 subClassOf NCIT_C176017 @default.
- NCIT_C117291 subClassOf NCIT_C1908 @default.
- NCIT_C117291 subClassOf NCIT_C1909 @default.
- NCIT_C117291 subClassOf NCIT_C274 @default.
- NCIT_C117291 subClassOf NCIT_C307 @default.
- NCIT_C117291 subClassOf NCIT_C308 @default.