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- NCIT_C117293 IAO_0000115 "An agonistic monoclonal antibody against the co-stimulatory receptor OX40 (CD134), with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, anti-OX40 monoclonal antibody MEDI6469 selectively binds to and activates OX40. OX40 activation induces proliferation of effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote an immune response against the TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on T-lymphocytes and provides a co-stimulatory signal for the proliferation and survival of activated T-cells." @default.
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- NCIT_C117293 hasExactSynonym "Agonistic Anti-CD134 Monoclonal Antibody MEDI6469" @default.
- NCIT_C117293 hasExactSynonym "Agonistic Anti-OX40 Monoclonal Antibody MEDI6469" @default.
- NCIT_C117293 hasExactSynonym "MEDI-6469" @default.
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- NCIT_C117293 type Class @default.
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- NCIT_C117293 label "Agonistic Anti-OX40 Monoclonal Antibody MEDI6469" @default.
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