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- NCIT_C117294 IAO_0000115 "A radioconjugate and cationic lipophilic agent consisting of fluorobenzyl triphenyl phosphonium (FBnTP), labeled with the radioisotope fluorine F 18, with potential use as a tracer for both mitochondrial membrane potential (MMP) and apoptosis, and as a tumor imaging agent using positron emission tomography (PET). Upon administration, fluorine F 18 FBnTP is taken up by cells and its uptake and accumulation within mitochondria is directly correlated with MMP. Apoptosis causes a loss of membrane potential across the inner mitochondrial membrane which decreases FBnTP mitochondrial uptake. As apoptosis is suppressed in tumor cells, the FBnTP uptake is increased as compared to normal cells. This allows, upon PET, for the imaging of cancer cells. As apoptotic-inducing chemotherapeutic agents cause a collapse of MMP, this agent can also be used to assess the response of tumor cells to those chemotherapeutic agents." @default.
- NCIT_C117294 NCIT_NHC0 "C117294" @default.
- NCIT_C117294 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117294 NCIT_P107 "Fluorine F 18 Fluorobenzyl Triphenyl Phosphonium" @default.
- NCIT_C117294 NCIT_P108 "Fluorine F 18 Fluorobenzyl Triphenyl Phosphonium" @default.
- NCIT_C117294 NCIT_P207 "C1743496" @default.
- NCIT_C117294 NCIT_P322 "CTRP" @default.
- NCIT_C117294 NCIT_P329 "763663" @default.
- NCIT_C117294 NCIT_P330 "763663" @default.
- NCIT_C117294 NCIT_P399 "763663" @default.
- NCIT_C117294 normalizedInformationContent "100" @default.
- NCIT_C117294 referenceCount "1" @default.
- NCIT_C117294 hasExactSynonym "18F-FBnTP" @default.
- NCIT_C117294 hasExactSynonym "18F-fluorobenzyl Triphenyl Phosphonium" @default.
- NCIT_C117294 hasExactSynonym "Fluorine F 18 Fluorobenzyl Triphenyl Phosphonium" @default.
- NCIT_C117294 inSubset NCIT_C116977 @default.
- NCIT_C117294 inSubset NCIT_C116978 @default.
- NCIT_C117294 inSubset NCIT_C176424 @default.
- NCIT_C117294 type Class @default.
- NCIT_C117294 isDefinedBy ncit.owl @default.
- NCIT_C117294 label "Fluorine F 18 Fluorobenzyl Triphenyl Phosphonium" @default.
- NCIT_C117294 subClassOf NCIT_C117294 @default.
- NCIT_C117294 subClassOf NCIT_C1446 @default.
- NCIT_C117294 subClassOf NCIT_C1908 @default.
- NCIT_C117294 subClassOf NCIT_C1909 @default.
- NCIT_C117294 subClassOf NCIT_C2124 @default.