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- NCIT_C117723 IAO_0000115 "The orally bioavailable, mesylate salt form of the tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity. Upon administration, flumatinib inhibits the wild-type forms of Bcr-Abl, platelet-derived growth factor receptor (PDGFR) and mast/stem cell growth factor receptor (SCFR; c-Kit) and forms of these proteins with certain point mutations. This results in the inhibition of both Bcr-Abl-, PDGFR- and c-Kit-mediated signal transduction pathways, and the proliferation of tumor cells in which these kinases are overexpressed. Bcr-Abl fusion protein is an abnormal, constitutively active enzyme expressed in Philadelphia chromosome positive chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML). PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. c-kit, a receptor tyrosine kinase mutated and constitutively activated in certain tumors, plays a key role in tumor cell survival, proliferation, and differentiation." @default.
- NCIT_C117723 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117723 NCIT_A6 NCIT_C138991 @default.
- NCIT_C117723 NCIT_NHC0 "C117723" @default.
- NCIT_C117723 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117723 NCIT_P108 "Flumatinib Mesylate" @default.
- NCIT_C117723 NCIT_P207 "C2973571" @default.
- NCIT_C117723 NCIT_P210 "895519-91-2" @default.
- NCIT_C117723 NCIT_P319 "95Y8L63NBC" @default.
- NCIT_C117723 NCIT_P322 "FDA" @default.
- NCIT_C117723 NCIT_P322 "GDC" @default.
- NCIT_C117723 NCIT_P329 "763682" @default.
- NCIT_C117723 NCIT_P330 "763682" @default.
- NCIT_C117723 NCIT_P375 "Flumatinib Mesylate" @default.
- NCIT_C117723 NCIT_P399 "763682" @default.
- NCIT_C117723 normalizedInformationContent "100" @default.
- NCIT_C117723 referenceCount "1" @default.
- NCIT_C117723 hasExactSynonym "4-(4-Methyl-piperazin-1-ylmethyl)-N-[6-methyl-5-(4-pyridin-3-yl-pyrimidin-2-ylamino)-pyridin-3-yl]-3-trifluoromethyl-benzamide Mesylate" @default.
- NCIT_C117723 hasExactSynonym "FLUMATINIB MESYLATE" @default.
- NCIT_C117723 hasExactSynonym "Flumatinib Mesylate" @default.
- NCIT_C117723 hasExactSynonym "HH-GV-678 Mesylate" @default.
- NCIT_C117723 hasExactSynonym "HH-GV678 Mesylate" @default.
- NCIT_C117723 inSubset NCIT_C128784 @default.
- NCIT_C117723 inSubset NCIT_C157711 @default.
- NCIT_C117723 inSubset NCIT_C157712 @default.
- NCIT_C117723 inSubset NCIT_C176424 @default.
- NCIT_C117723 inSubset NCIT_C177537 @default.
- NCIT_C117723 inSubset NCIT_C63923 @default.
- NCIT_C117723 type Class @default.
- NCIT_C117723 isDefinedBy ncit.owl @default.
- NCIT_C117723 label "Flumatinib Mesylate" @default.
- NCIT_C117723 subClassOf NCIT_C117723 @default.
- NCIT_C117723 subClassOf NCIT_C129824 @default.
- NCIT_C117723 subClassOf NCIT_C129825 @default.
- NCIT_C117723 subClassOf NCIT_C1404 @default.
- NCIT_C117723 subClassOf NCIT_C1908 @default.
- NCIT_C117723 subClassOf NCIT_C1909 @default.
- NCIT_C117723 subClassOf NCIT_C1967 @default.
- NCIT_C117723 subClassOf NCIT_C2189 @default.
- NCIT_C117723 subClassOf NCIT_C274 @default.
- NCIT_C117723 subClassOf NCIT_C471 @default.