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- NCIT_C117727 IAO_0000115 "Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor variant III (EGFRvIII) mutant chimeric T-cell receptor (chimeric antigen receptor or CAR) gene, with potential immunostimulatory and antineoplastic activities. Upon administration, the EGFRvIII-specific CAR-transduced autologous T-lymphocytes bind to the EGFRvIII antigen on tumor cell surfaces; subsequently, EGFRvIII-expressing tumor cells may be lysed. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy." @default.
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- NCIT_C117727 NCIT_P107 "EGFRvIII-specific CAR-transduced Autologous T Lymphocytes" @default.
- NCIT_C117727 NCIT_P108 "EGFRvIII-specific CAR-transduced Autologous T Lymphocytes" @default.
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- NCIT_C117727 hasExactSynonym "CART-EGFRvIII Autologous T Cells" @default.
- NCIT_C117727 hasExactSynonym "EGFRvIII-specific CAR-transduced Autologous T Lymphocytes" @default.
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- NCIT_C117727 type Class @default.
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- NCIT_C117727 label "EGFRvIII-specific CAR-transduced Autologous T Lymphocytes" @default.
- NCIT_C117727 subClassOf NCIT_C117727 @default.
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