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- NCIT_C117730 IAO_0000115 "A humanized monoclonal antibody targeting the human cell surface antigen CD47, with potential immunostimulating and antineoplastic activities. Upon administration, magrolimab selectively binds to CD47 expressed on tumor cells and blocks the interaction of CD47 with its ligand signal regulatory protein alpha (SIRPa), a protein expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling, allows the activation of macrophages, through the induction of pro-phagocytic signaling mediated by calreticulin, which is specifically expressed on the surface of tumor cells, and results in specific tumor cell phagocytosis. In addition, blocking CD47 signaling activates an anti-tumor T-lymphocyte immune response and T-mediated cell killing. CD47, a tumor associated antigen expressed on normal, healthy hematopoietic stem cells (HSC), is overexpressed on the surface of a variety of cancer cells. Expression of CD47, and interaction with SIRP-alpha, leads to inhibition of macrophages and protects cancer cells from phagocytosis thereby allowing cancer cells to proliferate." @default.
- NCIT_C117730 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117730 NCIT_NHC0 "C117730" @default.
- NCIT_C117730 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C117730 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117730 NCIT_P108 "Magrolimab" @default.
- NCIT_C117730 NCIT_P208 "CL474125" @default.
- NCIT_C117730 NCIT_P210 "2169232-81-7" @default.
- NCIT_C117730 NCIT_P319 "90YIEHRFJ9" @default.
- NCIT_C117730 NCIT_P322 "FDA" @default.
- NCIT_C117730 NCIT_P322 "GDC" @default.
- NCIT_C117730 NCIT_P329 "763907" @default.
- NCIT_C117730 NCIT_P330 "763907" @default.
- NCIT_C117730 NCIT_P375 "Anti-CD47 Monoclonal Antibody Hu5F9-G4" @default.
- NCIT_C117730 NCIT_P375 "Magrolimab" @default.
- NCIT_C117730 NCIT_P399 "763907" @default.
- NCIT_C117730 NCIT_R124 NCIT_C17710 @default.
- NCIT_C117730 NCIT_R124 NCIT_C17828 @default.
- NCIT_C117730 NCIT_R124 NCIT_C18219 @default.
- NCIT_C117730 NCIT_R124 NCIT_C19986 @default.
- NCIT_C117730 NCIT_R124 NCIT_C40474 @default.
- NCIT_C117730 normalizedInformationContent "100" @default.
- NCIT_C117730 referenceCount "1" @default.
- NCIT_C117730 hasExactSynonym "Hu5F9-G4" @default.
- NCIT_C117730 hasExactSynonym "MAGROLIMAB" @default.
- NCIT_C117730 hasExactSynonym "Magrolimab" @default.
- NCIT_C117730 hasExactSynonym "ONO-7913" @default.
- NCIT_C117730 inSubset NCIT_C128784 @default.
- NCIT_C117730 inSubset NCIT_C157711 @default.
- NCIT_C117730 inSubset NCIT_C157712 @default.
- NCIT_C117730 inSubset NCIT_C176424 @default.
- NCIT_C117730 inSubset NCIT_C177537 @default.
- NCIT_C117730 inSubset NCIT_C63923 @default.
- NCIT_C117730 type Class @default.
- NCIT_C117730 isDefinedBy ncit.owl @default.
- NCIT_C117730 label "Magrolimab" @default.
- NCIT_C117730 subClassOf NCIT_C117730 @default.
- NCIT_C117730 subClassOf NCIT_C129821 @default.
- NCIT_C117730 subClassOf NCIT_C129822 @default.
- NCIT_C117730 subClassOf NCIT_C159583 @default.
- NCIT_C117730 subClassOf NCIT_C163758 @default.
- NCIT_C117730 subClassOf NCIT_C1908 @default.
- NCIT_C117730 subClassOf NCIT_C1909 @default.
- NCIT_C117730 subClassOf NCIT_C192655 @default.
- NCIT_C117730 subClassOf NCIT_C20401 @default.
- NCIT_C117730 subClassOf NCIT_C274 @default.
- NCIT_C117730 subClassOf NCIT_C307 @default.
- NCIT_C117730 subClassOf NCIT_C308 @default.