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- NCIT_C117731 IAO_0000115 "An orally bioavailable, nitroimidazole-based sulfamide, carbonic anhydrase IX (CAIX) inhibitor with potential antineoplastic activity. Upon administration, CAIX inhibitor DTP348 inhibits tumor-associated CAIX, a hypoxia-inducible transmembrane glycoprotein that catalyzes the reversible reaction and rapid interconversion of carbon dioxide and water to carbonic acid, protons, and bicarbonate ions. This prevents the acidification of the tumor's extracellular microenvironment and decreases the intracellular pH. This results in increased cell death in CAIX-expressing, hypoxic tumors. In addition, DTP348, through its nitroimidazole moiety, is able to sensitize hypoxic tumor cells to irradiation. CAIX is overexpressed in various tumors and plays a key role in intra- and extracellular pH regulation, cancer cell progression, survival, migration and invasion." @default.
- NCIT_C117731 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117731 NCIT_NHC0 "C117731" @default.
- NCIT_C117731 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117731 NCIT_P108 "CAIX Inhibitor DTP348" @default.
- NCIT_C117731 NCIT_P208 "CL474126" @default.
- NCIT_C117731 NCIT_P210 "1383370-92-0" @default.
- NCIT_C117731 NCIT_P319 "2HB46A9CNM" @default.
- NCIT_C117731 NCIT_P322 "FDA" @default.
- NCIT_C117731 NCIT_P322 "GDC" @default.
- NCIT_C117731 NCIT_P329 "763908" @default.
- NCIT_C117731 NCIT_P330 "763908" @default.
- NCIT_C117731 NCIT_P375 "CAIX Inhibitor DTP348" @default.
- NCIT_C117731 NCIT_P399 "763908" @default.
- NCIT_C117731 normalizedInformationContent "100" @default.
- NCIT_C117731 referenceCount "1" @default.
- NCIT_C117731 hasExactSynonym "2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethylsulfamide" @default.
- NCIT_C117731 hasExactSynonym "CAIX Inhibitor DTP348" @default.
- NCIT_C117731 hasExactSynonym "DTP-348" @default.
- NCIT_C117731 hasExactSynonym "DTP348" @default.
- NCIT_C117731 inSubset NCIT_C128784 @default.
- NCIT_C117731 inSubset NCIT_C157711 @default.
- NCIT_C117731 inSubset NCIT_C157712 @default.
- NCIT_C117731 inSubset NCIT_C176424 @default.
- NCIT_C117731 inSubset NCIT_C177537 @default.
- NCIT_C117731 inSubset NCIT_C63923 @default.
- NCIT_C117731 type Class @default.
- NCIT_C117731 isDefinedBy ncit.owl @default.
- NCIT_C117731 label "CAIX Inhibitor DTP348" @default.
- NCIT_C117731 subClassOf NCIT_C117731 @default.
- NCIT_C117731 subClassOf NCIT_C129824 @default.
- NCIT_C117731 subClassOf NCIT_C129825 @default.
- NCIT_C117731 subClassOf NCIT_C1908 @default.
- NCIT_C117731 subClassOf NCIT_C1909 @default.
- NCIT_C117731 subClassOf NCIT_C2189 @default.
- NCIT_C117731 subClassOf NCIT_C274 @default.
- NCIT_C117731 subClassOf NCIT_C29577 @default.
- NCIT_C117731 subClassOf NCIT_C471 @default.