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- NCIT_C117732 IAO_0000115 "An antibody-drug conjugate (ADC) containing an engineered cysteine monoclonal antibody (EC-mAb), directed against the extracellular domain of the human CD70 molecule, conjugated to the synthetic, cytotoxic, DNA minor-groove crosslinking agent, pyrrolobenzodiazepine (PBD) dimer, via a stable, protease-cleavable, peptide-based linker, with potential antineoplastic activity. The anti-CD70 antibody moiety of the anti-CD70 antibody-drug conjugate SGN-CD70A selectively binds to the extracellular domain of CD70 on tumor cell surfaces. Upon internalization, the PBD dimer moiety is released and covalently binds, through its imine moieties, to the N2 positions of guanines on opposite strands of DNA. This induces DNA double strand breaks and inhibits DNA replication, which lead to the inhibition of cell growth of tumor cells that overexpress CD70. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. The cysteine moiety of the EC-mAb allows for the stable conjugation of the PBD to the antibody." @default.
- NCIT_C117732 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117732 NCIT_NHC0 "C117732" @default.
- NCIT_C117732 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C117732 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117732 NCIT_P108 "Anti-CD70 Antibody-drug Conjugate SGN-CD70A" @default.
- NCIT_C117732 NCIT_P208 "CL474127" @default.
- NCIT_C117732 NCIT_P210 "1447736-02-8" @default.
- NCIT_C117732 NCIT_P319 "YFZ7N482WG" @default.
- NCIT_C117732 NCIT_P322 "FDA" @default.
- NCIT_C117732 NCIT_P322 "GDC" @default.
- NCIT_C117732 NCIT_P329 "763909" @default.
- NCIT_C117732 NCIT_P330 "763909" @default.
- NCIT_C117732 NCIT_P375 "Anti-CD70 Antibody-drug Conjugate SGN-CD70A" @default.
- NCIT_C117732 NCIT_P399 "763909" @default.
- NCIT_C117732 normalizedInformationContent "100" @default.
- NCIT_C117732 referenceCount "1" @default.
- NCIT_C117732 hasExactSynonym "Anti-CD70 Antibody-drug Conjugate SGN-CD70A" @default.
- NCIT_C117732 hasExactSynonym "SGN-CD70A" @default.
- NCIT_C117732 inSubset NCIT_C128784 @default.
- NCIT_C117732 inSubset NCIT_C157711 @default.
- NCIT_C117732 inSubset NCIT_C157712 @default.
- NCIT_C117732 inSubset NCIT_C176424 @default.
- NCIT_C117732 inSubset NCIT_C177537 @default.
- NCIT_C117732 inSubset NCIT_C63923 @default.
- NCIT_C117732 type Class @default.
- NCIT_C117732 isDefinedBy ncit.owl @default.
- NCIT_C117732 label "Anti-CD70 Antibody-drug Conjugate SGN-CD70A" @default.
- NCIT_C117732 subClassOf NCIT_C117732 @default.
- NCIT_C117732 subClassOf NCIT_C129821 @default.
- NCIT_C117732 subClassOf NCIT_C129823 @default.
- NCIT_C117732 subClassOf NCIT_C1512 @default.
- NCIT_C117732 subClassOf NCIT_C163758 @default.
- NCIT_C117732 subClassOf NCIT_C1908 @default.
- NCIT_C117732 subClassOf NCIT_C1909 @default.
- NCIT_C117732 subClassOf NCIT_C200042 @default.
- NCIT_C117732 subClassOf NCIT_C201550 @default.
- NCIT_C117732 subClassOf NCIT_C274 @default.
- NCIT_C117732 subClassOf NCIT_C307 @default.
- NCIT_C117732 subClassOf NCIT_C308 @default.