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- NCIT_C117734 IAO_0000115 "An orally bioavailable, receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Upon administration, sitravatinib binds to and inhibits the activity of several RTKs including hepatocyte growth factor receptor (HGFR; c-Met; MET), tyrosine-protein kinase receptor UFO (AXL receptor tyrosine kinase; AXL), mast/stem cell growth factor receptor (SCFR; c-kit; KIT), the receptor tyrosine kinase MER, discoidin domain receptor 2 (DDR2), vascular endothelial growth factor receptor (VEGFR) types 1 (VEGFR-1; FLT1), 2 (VEGFR-2; KDR; Flk-1) and 3 (VEGFR-3), members of the platelet-derived growth factor receptor (PDGFR) family, RET (rearranged during transfection), tropomyosin-related kinases (TRK) and members of the ephrin (Eph) family of receptor tyrosine kinases. This may result in both the inhibition of signal transduction pathways mediated by these RTKs and the reduction of tumor cell proliferation in cancer cell types that overexpress these RTKs." @default.
- NCIT_C117734 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117734 NCIT_NHC0 "C117734" @default.
- NCIT_C117734 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117734 NCIT_P108 "Sitravatinib" @default.
- NCIT_C117734 NCIT_P208 "CL474129" @default.
- NCIT_C117734 NCIT_P210 "1123837-84-2" @default.
- NCIT_C117734 NCIT_P319 "CWG62Q1VTB" @default.
- NCIT_C117734 NCIT_P322 "FDA" @default.
- NCIT_C117734 NCIT_P322 "GDC" @default.
- NCIT_C117734 NCIT_P329 "764051" @default.
- NCIT_C117734 NCIT_P330 "764051" @default.
- NCIT_C117734 NCIT_P375 "Sitravatinib" @default.
- NCIT_C117734 NCIT_P399 "764051" @default.
- NCIT_C117734 normalizedInformationContent "100" @default.
- NCIT_C117734 referenceCount "1" @default.
- NCIT_C117734 hasExactSynonym "1,1-Cyclopropanedicarboxamide, N-(3-Fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)-2-pyridinyl)thieno(3,2-b)pyridin-7-yl)oxy)phenyl)-N'-(4-fluorophenyl)-" @default.
- NCIT_C117734 hasExactSynonym "MGCD516" @default.
- NCIT_C117734 hasExactSynonym "SITRAVATINIB" @default.
- NCIT_C117734 hasExactSynonym "Sitravatinib" @default.
- NCIT_C117734 inSubset NCIT_C128784 @default.
- NCIT_C117734 inSubset NCIT_C157711 @default.
- NCIT_C117734 inSubset NCIT_C157712 @default.
- NCIT_C117734 inSubset NCIT_C176424 @default.
- NCIT_C117734 inSubset NCIT_C177537 @default.
- NCIT_C117734 inSubset NCIT_C63923 @default.
- NCIT_C117734 type Class @default.
- NCIT_C117734 isDefinedBy ncit.owl @default.
- NCIT_C117734 label "Sitravatinib" @default.
- NCIT_C117734 subClassOf NCIT_C117734 @default.
- NCIT_C117734 subClassOf NCIT_C129824 @default.
- NCIT_C117734 subClassOf NCIT_C129825 @default.
- NCIT_C117734 subClassOf NCIT_C1404 @default.
- NCIT_C117734 subClassOf NCIT_C1742 @default.
- NCIT_C117734 subClassOf NCIT_C1908 @default.
- NCIT_C117734 subClassOf NCIT_C1909 @default.
- NCIT_C117734 subClassOf NCIT_C1967 @default.
- NCIT_C117734 subClassOf NCIT_C200418 @default.
- NCIT_C117734 subClassOf NCIT_C2189 @default.
- NCIT_C117734 subClassOf NCIT_C274 @default.
- NCIT_C117734 subClassOf NCIT_C471 @default.