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- NCIT_C117735 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of a humanized monoclonal antibody against the stem cell factor receptor c-Kit (SCFR) and conjugated, via a non-cleavable linker, to the cytotoxic agent maytansine, with potential antineoplastic activity. The monoclonal antibody moiety of anti c-KIT ADC LOP628 targets and binds to the cell surface antigen c-Kit. After antibody-antigen interaction followed by internalization, the maytansine moiety binds to tubulin, inhibits microtubule assembly, and induces microtubule disassembly. This leads to a disruption of mitosis and the inhibition of cell proliferation in cancer cells expressing c-Kit. c-Kit, a transmembrane protein and receptor tyrosine kinase, is overexpressed in solid tumors and hematological malignancies; it plays a key role in the regulation of cell differentiation and proliferation." @default.
- NCIT_C117735 NCIT_A32 NCIT_C1909 @default.
- NCIT_C117735 NCIT_NHC0 "C117735" @default.
- NCIT_C117735 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C117735 NCIT_P108 "Anti c-KIT Antibody-drug Conjugate LOP628" @default.
- NCIT_C117735 NCIT_P208 "CL474131" @default.
- NCIT_C117735 NCIT_P322 "GDC" @default.
- NCIT_C117735 NCIT_P329 "764075" @default.
- NCIT_C117735 NCIT_P330 "764075" @default.
- NCIT_C117735 NCIT_P375 "Anti c-KIT Antibody-drug Conjugate LOP628" @default.
- NCIT_C117735 NCIT_P399 "764075" @default.
- NCIT_C117735 normalizedInformationContent "100" @default.
- NCIT_C117735 referenceCount "1" @default.
- NCIT_C117735 hasExactSynonym "Anti c-KIT ADC LOP628" @default.
- NCIT_C117735 hasExactSynonym "Anti c-KIT Antibody-drug Conjugate LOP628" @default.
- NCIT_C117735 hasExactSynonym "LOP628" @default.
- NCIT_C117735 inSubset NCIT_C128784 @default.
- NCIT_C117735 inSubset NCIT_C157711 @default.
- NCIT_C117735 inSubset NCIT_C157712 @default.
- NCIT_C117735 inSubset NCIT_C176424 @default.
- NCIT_C117735 inSubset NCIT_C177537 @default.
- NCIT_C117735 type Class @default.
- NCIT_C117735 isDefinedBy ncit.owl @default.
- NCIT_C117735 label "Anti c-KIT Antibody-drug Conjugate LOP628" @default.
- NCIT_C117735 subClassOf NCIT_C117735 @default.
- NCIT_C117735 subClassOf NCIT_C129821 @default.
- NCIT_C117735 subClassOf NCIT_C129823 @default.
- NCIT_C117735 subClassOf NCIT_C1512 @default.
- NCIT_C117735 subClassOf NCIT_C163758 @default.
- NCIT_C117735 subClassOf NCIT_C163999 @default.
- NCIT_C117735 subClassOf NCIT_C1908 @default.
- NCIT_C117735 subClassOf NCIT_C1909 @default.
- NCIT_C117735 subClassOf NCIT_C274 @default.
- NCIT_C117735 subClassOf NCIT_C307 @default.
- NCIT_C117735 subClassOf NCIT_C308 @default.