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- NCIT_C1181 IAO_0000115 "An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04)" @default.
- NCIT_C1181 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1181 NCIT_A7 NCIT_C449 @default.
- NCIT_C1181 NCIT_NHC0 "C1181" @default.
- NCIT_C1181 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1181 NCIT_P107 "Oxaliplatin" @default.
- NCIT_C1181 NCIT_P108 "Oxaliplatin" @default.
- NCIT_C1181 NCIT_P175 "266046" @default.
- NCIT_C1181 NCIT_P207 "C0069717" @default.
- NCIT_C1181 NCIT_P210 "61825-94-3" @default.
- NCIT_C1181 NCIT_P302 "Metastatic colorectal cancer; ovarian cancer" @default.
- NCIT_C1181 NCIT_P319 "04ZR38536J" @default.
- NCIT_C1181 NCIT_P322 "CTRP" @default.
- NCIT_C1181 NCIT_P322 "FDA" @default.
- NCIT_C1181 NCIT_P322 "GDC" @default.
- NCIT_C1181 NCIT_P325 "A drug used with other drugs to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. Eloxatin attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound." @default.
- NCIT_C1181 NCIT_P329 "42374" @default.
- NCIT_C1181 NCIT_P330 "42374" @default.
- NCIT_C1181 NCIT_P350 "C8H14N2O4Pt" @default.
- NCIT_C1181 NCIT_P366 "Oxaliplatin" @default.
- NCIT_C1181 NCIT_P368 "CHEBI:31941" @default.
- NCIT_C1181 NCIT_P375 "Oxaliplatin" @default.
- NCIT_C1181 NCIT_P399 "42374" @default.
- NCIT_C1181 NCIT_R124 NCIT_C16507 @default.
- NCIT_C1181 NCIT_R124 NCIT_C16956 @default.
- NCIT_C1181 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1181 NCIT_R124 NCIT_C18264 @default.
- NCIT_C1181 NCIT_R124 NCIT_C19154 @default.
- NCIT_C1181 NCIT_R124 NCIT_C25827 @default.
- NCIT_C1181 NCIT_R125 NCIT_C17557 @default.
- NCIT_C1181 NCIT_R125 NCIT_C17710 @default.
- NCIT_C1181 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1181 NCIT_R125 NCIT_C18125 @default.
- NCIT_C1181 NCIT_R125 NCIT_C19077 @default.
- NCIT_C1181 NCIT_R125 NCIT_C20480 @default.
- NCIT_C1181 NCIT_R125 NCIT_C21049 @default.
- NCIT_C1181 NCIT_R125 NCIT_C21050 @default.
- NCIT_C1181 NCIT_R125 NCIT_C21080 @default.
- NCIT_C1181 NCIT_R125 NCIT_C28498 @default.
- NCIT_C1181 NCIT_R125 NCIT_C40664 @default.
- NCIT_C1181 NCIT_R125 NCIT_C40692 @default.
- NCIT_C1181 NCIT_R125 NCIT_C41515 @default.
- NCIT_C1181 NCIT_R125 NCIT_C41543 @default.
- NCIT_C1181 normalizedInformationContent "71.609334258173831" @default.
- NCIT_C1181 referenceCount "73" @default.
- NCIT_C1181 hasExactSynonym "1-OHP" @default.
- NCIT_C1181 hasExactSynonym "Ai Heng" @default.
- NCIT_C1181 hasExactSynonym "Aiheng" @default.
- NCIT_C1181 hasExactSynonym "DACPLAT" @default.
- NCIT_C1181 hasExactSynonym "Dacotin" @default.
- NCIT_C1181 hasExactSynonym "Dacplat" @default.
- NCIT_C1181 hasExactSynonym "Diaminocyclohexane Oxalatoplatinum" @default.
- NCIT_C1181 hasExactSynonym "ELOXATIN" @default.
- NCIT_C1181 hasExactSynonym "Eloxatin" @default.
- NCIT_C1181 hasExactSynonym "Eloxatine" @default.
- NCIT_C1181 hasExactSynonym "JM-83" @default.
- NCIT_C1181 hasExactSynonym "OXALIPLATIN" @default.
- NCIT_C1181 hasExactSynonym "Oxalatoplatin" @default.
- NCIT_C1181 hasExactSynonym "Oxalatoplatinum" @default.
- NCIT_C1181 hasExactSynonym "Oxaliplatin" @default.
- NCIT_C1181 hasExactSynonym "RP 54780" @default.
- NCIT_C1181 hasExactSynonym "RP-54780" @default.
- NCIT_C1181 hasExactSynonym "SR-96669" @default.
- NCIT_C1181 hasExactSynonym "[(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum" @default.
- NCIT_C1181 hasExactSynonym "[SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum" @default.
- NCIT_C1181 hasExactSynonym "oxalato (1R,2R-cyclohexanediamine)platinum(II)" @default.
- NCIT_C1181 hasExactSynonym "oxalato (trans-l-1,2-diaminocyclohexane)platinum(II)" @default.
- NCIT_C1181 hasExactSynonym "oxaliplatin" @default.
- NCIT_C1181 hasExactSynonym "trans-l DACH oxalatoplatinum" @default.
- NCIT_C1181 hasExactSynonym "trans-l diaminocyclohexane oxalatoplatinum" @default.
- NCIT_C1181 inSubset NCIT_C116977 @default.
- NCIT_C1181 inSubset NCIT_C116978 @default.
- NCIT_C1181 inSubset NCIT_C128784 @default.
- NCIT_C1181 inSubset NCIT_C157711 @default.
- NCIT_C1181 inSubset NCIT_C157712 @default.
- NCIT_C1181 inSubset NCIT_C176424 @default.
- NCIT_C1181 inSubset NCIT_C177537 @default.
- NCIT_C1181 inSubset NCIT_C63923 @default.
- NCIT_C1181 type Class @default.
- NCIT_C1181 isDefinedBy ncit.owl @default.
- NCIT_C1181 label "Oxaliplatin" @default.
- NCIT_C1181 subClassOf B17f66373d9ceaee3bf315f6d26958f2b @default.
- NCIT_C1181 subClassOf B253152032ec3a9c296034ef7f4ee6929 @default.
- NCIT_C1181 subClassOf B2d6908d7c367ecdd188d4ae1b63371ba @default.
- NCIT_C1181 subClassOf B32befd2d4057f2646f70a22ea1e80fae @default.
- NCIT_C1181 subClassOf B75e338393c1350168cc4f72da2c0d1a9 @default.
- NCIT_C1181 subClassOf Bce0a87ee86cc91b5c7767cb6463a1318 @default.
- NCIT_C1181 subClassOf Bf08d26071257e57beb2f2f7580bb4e1d @default.
- NCIT_C1181 subClassOf Bf9aa815be9f97223de2183f0ab3669ec @default.
- NCIT_C1181 subClassOf NCIT_C1181 @default.
- NCIT_C1181 subClassOf NCIT_C1450 @default.
- NCIT_C1181 subClassOf NCIT_C1590 @default.
- NCIT_C1181 subClassOf NCIT_C186664 @default.
- NCIT_C1181 subClassOf NCIT_C1908 @default.
- NCIT_C1181 subClassOf NCIT_C1909 @default.
- NCIT_C1181 subClassOf NCIT_C2163 @default.
- NCIT_C1181 subClassOf NCIT_C274 @default.
- NCIT_C1181 subClassOf NCIT_C2842 @default.
- NCIT_C1181 subClassOf NCIT_C798 @default.