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- NCIT_C118282 IAO_0000115 "An agonistic monoclonal antibody against receptor OX40 (CD134), with potential immunostimulatory activity. Upon administration, efizonerimod selectively binds to and activates the OX40 receptor, by mimicking the action of endogenous OX40 ligand (OX40L). OX40 receptor activation induces proliferation of memory and effector T lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote an immune response against the TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor family, is expressed on T-lymphocytes and provides a co-stimulatory signal for the proliferation and survival of activated T cells." @default.
- NCIT_C118282 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118282 NCIT_A7 NCIT_C94790 @default.
- NCIT_C118282 NCIT_NHC0 "C118282" @default.
- NCIT_C118282 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C118282 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C118282 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118282 NCIT_P108 "Efizonerimod" @default.
- NCIT_C118282 NCIT_P208 "CL474134" @default.
- NCIT_C118282 NCIT_P210 "1635395-27-5" @default.
- NCIT_C118282 NCIT_P319 "1MH7C2X8KE" @default.
- NCIT_C118282 NCIT_P322 "FDA" @default.
- NCIT_C118282 NCIT_P322 "GDC" @default.
- NCIT_C118282 NCIT_P329 "764233" @default.
- NCIT_C118282 NCIT_P330 "764233" @default.
- NCIT_C118282 NCIT_P375 "Efizonerimod" @default.
- NCIT_C118282 NCIT_P399 "764233" @default.
- NCIT_C118282 NCIT_R124 NCIT_C17710 @default.
- NCIT_C118282 NCIT_R124 NCIT_C17828 @default.
- NCIT_C118282 NCIT_R124 NCIT_C18219 @default.
- NCIT_C118282 NCIT_R124 NCIT_C19986 @default.
- NCIT_C118282 NCIT_R124 NCIT_C40474 @default.
- NCIT_C118282 NCIT_R125 NCIT_C16298 @default.
- NCIT_C118282 NCIT_R125 NCIT_C17709 @default.
- NCIT_C118282 NCIT_R125 NCIT_C17828 @default.
- NCIT_C118282 NCIT_R125 NCIT_C17930 @default.
- NCIT_C118282 NCIT_R125 NCIT_C17937 @default.
- NCIT_C118282 NCIT_R125 NCIT_C18839 @default.
- NCIT_C118282 NCIT_R125 NCIT_C21124 @default.
- NCIT_C118282 NCIT_R72 NCIT_C104083 @default.
- NCIT_C118282 NCIT_R72 NCIT_C12219 @default.
- NCIT_C118282 NCIT_R72 NCIT_C12474 @default.
- NCIT_C118282 NCIT_R72 NCIT_C12476 @default.
- NCIT_C118282 NCIT_R72 NCIT_C12508 @default.
- NCIT_C118282 NCIT_R72 NCIT_C12535 @default.
- NCIT_C118282 NCIT_R72 NCIT_C12542 @default.
- NCIT_C118282 NCIT_R72 NCIT_C12543 @default.
- NCIT_C118282 NCIT_R72 NCIT_C21599 @default.
- NCIT_C118282 NCIT_R72 NCIT_C32725 @default.
- NCIT_C118282 NCIT_R72 NCIT_C33061 @default.
- NCIT_C118282 NCIT_R72 NCIT_C38434 @default.
- NCIT_C118282 NCIT_R72 NCIT_C38439 @default.
- NCIT_C118282 NCIT_R72 NCIT_C39567 @default.
- NCIT_C118282 NCIT_R72 NCIT_C39568 @default.
- NCIT_C118282 normalizedInformationContent "100" @default.
- NCIT_C118282 referenceCount "1" @default.
- NCIT_C118282 hasExactSynonym "EFIZONERIMOD" @default.
- NCIT_C118282 hasExactSynonym "Efizonerimod Alfa" @default.
- NCIT_C118282 hasExactSynonym "Efizonerimod" @default.
- NCIT_C118282 hasExactSynonym "Immunoglobulin G4 (10-proline) (Human Heavy Chain Fc Fragment) Fusion Protein with Tumor Necrosis Factor Receptor-associated Factor TRAF2 (Human C-C Domain Fragment) Fusion Protein with CD252 Antigen (Human Extracellular Domain Fragment), Hexamer" @default.
- NCIT_C118282 hasExactSynonym "MEDI6383" @default.
- NCIT_C118282 inSubset NCIT_C128784 @default.
- NCIT_C118282 inSubset NCIT_C157711 @default.
- NCIT_C118282 inSubset NCIT_C157712 @default.
- NCIT_C118282 inSubset NCIT_C176424 @default.
- NCIT_C118282 inSubset NCIT_C177537 @default.
- NCIT_C118282 inSubset NCIT_C63923 @default.
- NCIT_C118282 type Class @default.
- NCIT_C118282 isDefinedBy ncit.owl @default.
- NCIT_C118282 label "Efizonerimod" @default.
- NCIT_C118282 subClassOf B074f42f7d153d2b2f2bc85e9dcba4be4 @default.
- NCIT_C118282 subClassOf B7af852f8e4e0880f0d245adc50d1d999 @default.
- NCIT_C118282 subClassOf NCIT_C118282 @default.
- NCIT_C118282 subClassOf NCIT_C129821 @default.
- NCIT_C118282 subClassOf NCIT_C129822 @default.
- NCIT_C118282 subClassOf NCIT_C141144 @default.
- NCIT_C118282 subClassOf NCIT_C1908 @default.
- NCIT_C118282 subClassOf NCIT_C1909 @default.
- NCIT_C118282 subClassOf NCIT_C20401 @default.
- NCIT_C118282 subClassOf NCIT_C274 @default.
- NCIT_C118282 subClassOf NCIT_C307 @default.
- NCIT_C118282 subClassOf NCIT_C308 @default.
- NCIT_C118282 subClassOf NCIT_C96040 @default.