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- NCIT_C118285 IAO_0000115 "An orally bioavailable fatty acid synthase (FASN) inhibitor, with potential antineoplastic activity. Upon administration, denifanstat binds to and blocks FASN, which prevents the synthesis of palmitate needed for tumor cell growth and survival. This leads to a reduction in cell signaling, an induction of tumor cell apoptosis and the inhibition of cell proliferation in susceptible tumor cells. FASN, an enzyme responsible for the de novo synthesis of palmitic acid, is overexpressed in tumor cells and plays a key role in tumor metabolism, lipid signaling, tumor cell survival and drug resistance; tumor cells are dependent on increased fatty acid production for their enhanced metabolic needs and rapid growth." @default.
- NCIT_C118285 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118285 NCIT_A7 NCIT_C16574 @default.
- NCIT_C118285 NCIT_NHC0 "C118285" @default.
- NCIT_C118285 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118285 NCIT_P107 "Denifanstat" @default.
- NCIT_C118285 NCIT_P108 "Denifanstat" @default.
- NCIT_C118285 NCIT_P208 "CL474138" @default.
- NCIT_C118285 NCIT_P210 "1399177-37-7" @default.
- NCIT_C118285 NCIT_P319 "4GF95B2LZA" @default.
- NCIT_C118285 NCIT_P322 "CTRP" @default.
- NCIT_C118285 NCIT_P322 "FDA" @default.
- NCIT_C118285 NCIT_P322 "GDC" @default.
- NCIT_C118285 NCIT_P329 "764237" @default.
- NCIT_C118285 NCIT_P330 "764237" @default.
- NCIT_C118285 NCIT_P375 "FASN Inhibitor TVB-2640" @default.
- NCIT_C118285 NCIT_P399 "764237" @default.
- NCIT_C118285 normalizedInformationContent "100" @default.
- NCIT_C118285 referenceCount "1" @default.
- NCIT_C118285 hasExactSynonym "ASC 40" @default.
- NCIT_C118285 hasExactSynonym "ASC-40" @default.
- NCIT_C118285 hasExactSynonym "ASC40" @default.
- NCIT_C118285 hasExactSynonym "DENIFANSTAT" @default.
- NCIT_C118285 hasExactSynonym "Denifanstat" @default.
- NCIT_C118285 hasExactSynonym "FASN Inhibitor TVB-2640" @default.
- NCIT_C118285 hasExactSynonym "TVB 2640" @default.
- NCIT_C118285 hasExactSynonym "TVB-2640" @default.
- NCIT_C118285 hasExactSynonym "TVB2640" @default.
- NCIT_C118285 inSubset NCIT_C116977 @default.
- NCIT_C118285 inSubset NCIT_C116978 @default.
- NCIT_C118285 inSubset NCIT_C128784 @default.
- NCIT_C118285 inSubset NCIT_C157711 @default.
- NCIT_C118285 inSubset NCIT_C157712 @default.
- NCIT_C118285 inSubset NCIT_C176424 @default.
- NCIT_C118285 inSubset NCIT_C177537 @default.
- NCIT_C118285 inSubset NCIT_C63923 @default.
- NCIT_C118285 type Class @default.
- NCIT_C118285 isDefinedBy ncit.owl @default.
- NCIT_C118285 label "Denifanstat" @default.
- NCIT_C118285 subClassOf NCIT_C118285 @default.
- NCIT_C118285 subClassOf NCIT_C1908 @default.
- NCIT_C118285 subClassOf NCIT_C1909 @default.
- NCIT_C118285 subClassOf NCIT_C471 @default.