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- NCIT_C118287 IAO_0000115 "An orally bioavailable inhibitor of valosin-containing protein (VCP) p97, with potential antineoplastic activity. Upon oral administration, CB-5083 specifically binds to and inhibits the activity of p97. This prevents ubiquitin-dependent protein degradation and causes cellular accumulation of poly-ubiquitinated proteins. The inhibition of endoplasmic reticulum (ER)-associated protein degradation activates the ER-dependent stress response pathway, and leads to both an induction of apoptosis and inhibition of cell proliferation in susceptible tumor cells. p97, a type II AAA ATPase, plays a key role in cellular protein homeostasis. Its overexpression in many tumor cell types is associated with increased tumor cell proliferation and survival." @default.
- NCIT_C118287 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118287 NCIT_NHC0 "C118287" @default.
- NCIT_C118287 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118287 NCIT_P108 "p97 Inhibitor CB-5083" @default.
- NCIT_C118287 NCIT_P207 "C3896891" @default.
- NCIT_C118287 NCIT_P210 "1542705-92-9" @default.
- NCIT_C118287 NCIT_P319 "591IV6UL6J" @default.
- NCIT_C118287 NCIT_P322 "FDA" @default.
- NCIT_C118287 NCIT_P322 "GDC" @default.
- NCIT_C118287 NCIT_P329 "764238" @default.
- NCIT_C118287 NCIT_P330 "764238" @default.
- NCIT_C118287 NCIT_P375 "p97 Inhibitor CB-5083" @default.
- NCIT_C118287 NCIT_P399 "764238" @default.
- NCIT_C118287 normalizedInformationContent "100" @default.
- NCIT_C118287 referenceCount "1" @default.
- NCIT_C118287 hasExactSynonym "CB-5083" @default.
- NCIT_C118287 hasExactSynonym "p97 Inhibitor CB-5083" @default.
- NCIT_C118287 inSubset NCIT_C128784 @default.
- NCIT_C118287 inSubset NCIT_C157711 @default.
- NCIT_C118287 inSubset NCIT_C157712 @default.
- NCIT_C118287 inSubset NCIT_C176424 @default.
- NCIT_C118287 inSubset NCIT_C177537 @default.
- NCIT_C118287 inSubset NCIT_C63923 @default.
- NCIT_C118287 type Class @default.
- NCIT_C118287 isDefinedBy ncit.owl @default.
- NCIT_C118287 label "p97 Inhibitor CB-5083" @default.
- NCIT_C118287 subClassOf NCIT_C118287 @default.
- NCIT_C118287 subClassOf NCIT_C1908 @default.
- NCIT_C118287 subClassOf NCIT_C1909 @default.
- NCIT_C118287 subClassOf NCIT_C471 @default.