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- NCIT_C118288 IAO_0000115 "An orally bioavailable formulation of azacitidine, a pyrimidine nucleoside analogue of cytidine, with antineoplastic activity. Upon oral administration, azacitidine is taken up by cells and metabolized to 5-azadeoxycitidine triphosphate. The incorporation of 5-azadeoxycitidine triphosphate into DNA reversibly inhibits DNA methyltransferase, and blocks DNA methylation. Hypomethylation of DNA by azacitidine may re-activate tumor suppressor genes previously silenced by hypermethylation, resulting in an antitumor effect. In addition, the incorporation of 5-azacitidine triphosphate into RNA disrupts normal RNA function and impairs tRNA (cytosine-5)-methyltransferase activity, resulting in an inhibition of RNA and protein synthesis." @default.
- NCIT_C118288 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118288 NCIT_NHC0 "C118288" @default.
- NCIT_C118288 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C118288 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118288 NCIT_P108 "Oral Azacitidine" @default.
- NCIT_C118288 NCIT_P208 "CL474140" @default.
- NCIT_C118288 NCIT_P322 "GDC" @default.
- NCIT_C118288 NCIT_P329 "764239" @default.
- NCIT_C118288 NCIT_P330 "764239" @default.
- NCIT_C118288 NCIT_P375 "Oral Azacitidine" @default.
- NCIT_C118288 NCIT_P399 "764239" @default.
- NCIT_C118288 normalizedInformationContent "100" @default.
- NCIT_C118288 referenceCount "1" @default.
- NCIT_C118288 hasExactSynonym "Azacitidine Oral" @default.
- NCIT_C118288 hasExactSynonym "CC-486" @default.
- NCIT_C118288 hasExactSynonym "Oral Azacitidine" @default.
- NCIT_C118288 inSubset NCIT_C128784 @default.
- NCIT_C118288 inSubset NCIT_C157711 @default.
- NCIT_C118288 inSubset NCIT_C157712 @default.
- NCIT_C118288 inSubset NCIT_C176424 @default.
- NCIT_C118288 inSubset NCIT_C177537 @default.
- NCIT_C118288 type Class @default.
- NCIT_C118288 isDefinedBy ncit.owl @default.
- NCIT_C118288 label "Oral Azacitidine" @default.
- NCIT_C118288 subClassOf NCIT_C118288 @default.
- NCIT_C118288 subClassOf NCIT_C1557 @default.
- NCIT_C118288 subClassOf NCIT_C186664 @default.
- NCIT_C118288 subClassOf NCIT_C1908 @default.
- NCIT_C118288 subClassOf NCIT_C1909 @default.
- NCIT_C118288 subClassOf NCIT_C272 @default.
- NCIT_C118288 subClassOf NCIT_C274 @default.