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- NCIT_C118294 IAO_0000115 "An orally available multikinase inhibitor that targets Raf kinase and various receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Upon oral administration, donafenib binds to and blocks the activity of Raf kinase, and inhibits Raf-mediated signal transduction pathways. This inhibits cell proliferation in Raf-expressing tumor cells. In addition, this agent may inhibit unidentified RTKs, and thus may further block tumor cell proliferation in susceptible tumor cells. Raf, a serine/threonine protein kinase, plays a key role in the Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway. Deregulation of this pathway often results in tumor cell proliferation and survival." @default.
- NCIT_C118294 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118294 NCIT_NHC0 "C118294" @default.
- NCIT_C118294 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118294 NCIT_P108 "Donafenib" @default.
- NCIT_C118294 NCIT_P207 "C3899341" @default.
- NCIT_C118294 NCIT_P210 "1130115-44-4" @default.
- NCIT_C118294 NCIT_P319 "41XGO0VS1U" @default.
- NCIT_C118294 NCIT_P322 "FDA" @default.
- NCIT_C118294 NCIT_P322 "GDC" @default.
- NCIT_C118294 NCIT_P329 "764413" @default.
- NCIT_C118294 NCIT_P330 "764413" @default.
- NCIT_C118294 NCIT_P375 "Donafenib" @default.
- NCIT_C118294 NCIT_P399 "764413" @default.
- NCIT_C118294 normalizedInformationContent "100" @default.
- NCIT_C118294 referenceCount "1" @default.
- NCIT_C118294 hasExactSynonym "2-Pyridinecarboxamide, 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-(methyl-d3)-" @default.
- NCIT_C118294 hasExactSynonym "4-(4-((4-Chloro-3-(trifluoromethyl)phenyl)carbamoylamino)phenoxy)-N-(trideuteriomethyl)pyridine-2-carboxamide" @default.
- NCIT_C118294 hasExactSynonym "CM-4307" @default.
- NCIT_C118294 hasExactSynonym "DONAFENIB" @default.
- NCIT_C118294 hasExactSynonym "Donafenib" @default.
- NCIT_C118294 inSubset NCIT_C128784 @default.
- NCIT_C118294 inSubset NCIT_C157711 @default.
- NCIT_C118294 inSubset NCIT_C157712 @default.
- NCIT_C118294 inSubset NCIT_C176424 @default.
- NCIT_C118294 inSubset NCIT_C177537 @default.
- NCIT_C118294 inSubset NCIT_C63923 @default.
- NCIT_C118294 type Class @default.
- NCIT_C118294 isDefinedBy ncit.owl @default.
- NCIT_C118294 label "Donafenib" @default.
- NCIT_C118294 subClassOf NCIT_C118294 @default.
- NCIT_C118294 subClassOf NCIT_C129824 @default.
- NCIT_C118294 subClassOf NCIT_C129825 @default.
- NCIT_C118294 subClassOf NCIT_C1404 @default.
- NCIT_C118294 subClassOf NCIT_C163758 @default.
- NCIT_C118294 subClassOf NCIT_C1908 @default.
- NCIT_C118294 subClassOf NCIT_C1909 @default.
- NCIT_C118294 subClassOf NCIT_C2189 @default.
- NCIT_C118294 subClassOf NCIT_C2336 @default.
- NCIT_C118294 subClassOf NCIT_C274 @default.
- NCIT_C118294 subClassOf NCIT_C471 @default.
- NCIT_C118294 subClassOf NCIT_C61074 @default.