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- NCIT_C118315 IAO_0000115 "An orally bioavailable, CaV3.2 T-type calcium channel blocker with potential anti-hyperalgesic activity. Upon oral administration, ABT-639 selectively binds to and blocks the CaV3.2 isoform of the low voltage-gated T-type calcium channels located in peripheral sensory neurons. This prevents the influx of calcium ions into the cell upon membrane depolarization. The inhibition of both neuronal hyperexcitability and firing of nociceptive, peripheral sensory neurons induces an anti-nociceptive effect. The expression of the CaV3.2 T-type channels plays a key role in nociceptive and neuropathic pain." @default.
- NCIT_C118315 NCIT_NHC0 "C118315" @default.
- NCIT_C118315 NCIT_P106 "Organic Chemical" @default.
- NCIT_C118315 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118315 NCIT_P107 "T-type Calcium Channel Blocker ABT-639" @default.
- NCIT_C118315 NCIT_P108 "T-type Calcium Channel Blocker ABT-639" @default.
- NCIT_C118315 NCIT_P207 "C3852853" @default.
- NCIT_C118315 NCIT_P210 "1235560-28-7" @default.
- NCIT_C118315 NCIT_P319 "0G7D0CQ88I" @default.
- NCIT_C118315 NCIT_P322 "CTRP" @default.
- NCIT_C118315 NCIT_P322 "FDA" @default.
- NCIT_C118315 NCIT_P329 "764585" @default.
- NCIT_C118315 NCIT_P330 "764585" @default.
- NCIT_C118315 NCIT_P399 "764585" @default.
- NCIT_C118315 normalizedInformationContent "100" @default.
- NCIT_C118315 referenceCount "1" @default.
- NCIT_C118315 hasExactSynonym "ABT-639" @default.
- NCIT_C118315 hasExactSynonym "Benzenesulfonamide, 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-(((8AR)-hexahydropyrrolo(1,2-A)pyrazin-2(1H)-yl)carbonyl)-" @default.
- NCIT_C118315 hasExactSynonym "T-type Calcium Channel Blocker ABT-639" @default.
- NCIT_C118315 inSubset NCIT_C116977 @default.
- NCIT_C118315 inSubset NCIT_C116978 @default.
- NCIT_C118315 inSubset NCIT_C176424 @default.
- NCIT_C118315 inSubset NCIT_C63923 @default.
- NCIT_C118315 type Class @default.
- NCIT_C118315 isDefinedBy ncit.owl @default.
- NCIT_C118315 label "T-type Calcium Channel Blocker ABT-639" @default.
- NCIT_C118315 subClassOf NCIT_C118315 @default.
- NCIT_C118315 subClassOf NCIT_C1908 @default.
- NCIT_C118315 subClassOf NCIT_C1909 @default.
- NCIT_C118315 subClassOf NCIT_C241 @default.
- NCIT_C118315 subClassOf NCIT_C245 @default.
- NCIT_C118315 subClassOf NCIT_C270 @default.
- NCIT_C118315 subClassOf NCIT_C333 @default.
- NCIT_C118315 subClassOf NCIT_C78272 @default.
- NCIT_C118315 subClassOf NCIT_C78274 @default.
- NCIT_C118315 subClassOf NCIT_C93038 @default.