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- NCIT_C118364 IAO_0000115 "A therapeutic cancer vaccine containing a truncated, synthetic peptide mimic of the human angiogenic activator vascular endothelial growth factor (VEGF), consisting of 79 amino acids (amino acids 26-104 of VEGF), and emulsified in the immunoadjuvant RFASE, with potential immunostimulatory and antitumor activities. Upon intramuscular vaccination, the hVEGF26-104 moiety of hVEGF26-104/RFASE acts as an antigen and induces an immune response against VEGF, which results in anti-VEGF antibody binding to and neutralization of endogenous VEGF. This prevents the binding of endogenous VEGF to the VEGF receptor (VEGFR) and blocks VEGFR-mediated endothelial cell signaling, resulting in an inhibition of both angiogenesis and tumor cell proliferation. VEGF plays a key role in angiogenesis, tumor cell proliferation and invasion. RFASE, which belongs to the group of sulpholipopolysaccharides (SLPs), is a synthetic polysaccharide covalently coupled to lipid groups and sulphate groups, and is able to induce a strong humoral immune response upon antigen administration." @default.
- NCIT_C118364 NCIT_NHC0 "C118364" @default.
- NCIT_C118364 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C118364 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118364 NCIT_P108 "hVEGF26-104/RFASE Peptide Vaccine" @default.
- NCIT_C118364 NCIT_P207 "C3897146" @default.
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- NCIT_C118364 hasExactSynonym "hVEGF26-104/RFASE Peptide Vaccine" @default.
- NCIT_C118364 hasExactSynonym "hVEGF26-104/RFASE" @default.
- NCIT_C118364 inSubset NCIT_C128784 @default.
- NCIT_C118364 inSubset NCIT_C176424 @default.
- NCIT_C118364 type Class @default.
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- NCIT_C118364 label "hVEGF26-104/RFASE Peptide Vaccine" @default.
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