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- NCIT_C118371 IAO_0000115 "An orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities. Upon administration, polaprezinc increases the expression of various anti-oxidant enzymes, such as superoxide dismutase 1 (SOD-1), SOD-2, heme oxygenase-1 (HO-1), glutathione S-transferase (GST), glutathione peroxidase (GSH-px), peroxidredoxin-1 (PRDX1; PRXI) and PRXD5 (PRXV) in the gastric mucosa, which protect cells against reactive oxygen species (ROS). In addition, this agent inhibits the activity of the transcription factor nuclear factor-kappaB (NF-kappaB) and reduces the expression of several pro-inflammatory cytokines, such as interleukin (IL) 1beta, IL-6, IL-8, and tumor necrosis factor alpha (TNF-a). Polaprezinc also increases the expression of various growth factors, such as platelet-derived growth factor-B (PDGF-B), vascular endothelial growth factor (VEGF), and nerve growth factor (NGF), and various heat shock proteins (HSPs), including HSP90, HSP70, HSP60, HSP47, HSP27, and HSP10. This protects against damages to, and accelerates healing of the gastric mucosa." @default.
- NCIT_C118371 NCIT_NHC0 "C118371" @default.
- NCIT_C118371 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118371 NCIT_P108 "Polaprezinc" @default.
- NCIT_C118371 NCIT_P207 "C0286382" @default.
- NCIT_C118371 NCIT_P210 "107667-60-7" @default.
- NCIT_C118371 NCIT_P319 "0WA1B15A1Z" @default.
- NCIT_C118371 NCIT_P322 "FDA" @default.
- NCIT_C118371 NCIT_P329 "764859" @default.
- NCIT_C118371 NCIT_P330 "764859" @default.
- NCIT_C118371 NCIT_P399 "764859" @default.
- NCIT_C118371 normalizedInformationContent "100" @default.
- NCIT_C118371 referenceCount "1" @default.
- NCIT_C118371 hasExactSynonym "Aprozinate" @default.
- NCIT_C118371 hasExactSynonym "Carnosine Zinc Complex" @default.
- NCIT_C118371 hasExactSynonym "POLAPREZINC" @default.
- NCIT_C118371 hasExactSynonym "Polaprezinc" @default.
- NCIT_C118371 hasExactSynonym "Z 103" @default.
- NCIT_C118371 hasExactSynonym "Zinc L-carnosine" @default.
- NCIT_C118371 hasExactSynonym "Zinc, (beta-alanyl-kappaN-L-histidinato(2-)-kappaN,kappaO)-" @default.
- NCIT_C118371 inSubset NCIT_C176424 @default.
- NCIT_C118371 inSubset NCIT_C63923 @default.
- NCIT_C118371 type Class @default.
- NCIT_C118371 isDefinedBy ncit.owl @default.
- NCIT_C118371 label "Polaprezinc" @default.
- NCIT_C118371 subClassOf NCIT_C118371 @default.
- NCIT_C118371 subClassOf NCIT_C1908 @default.
- NCIT_C118371 subClassOf NCIT_C1909 @default.
- NCIT_C118371 subClassOf NCIT_C26170 @default.
- NCIT_C118371 subClassOf NCIT_C29701 @default.
- NCIT_C118371 subClassOf NCIT_C78276 @default.