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- NCIT_C118443 IAO_0000115 "A monoclonal antibody directed against the ganglioside fucosyl-GM1, with potential antineoplastic and immunomodulating activities. Upon administration, anti-fucosyl-GM1 monoclonal antibody BMS-986012 binds to fucosyl-GM1 on cancer cells and may activate both antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity against the bound tumor cells. This may inhibit the proliferation of GM1-expressing tumor cells. Fucosyl-GM1, a sphingolipid monosialoganglioside and tumor associated antigen (TAA), is overexpressed on the surface of many cancer cells while its expression is minimal or non-existent in normal tissues." @default.
- NCIT_C118443 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118443 NCIT_A7 NCIT_C126894 @default.
- NCIT_C118443 NCIT_NHC0 "C118443" @default.
- NCIT_C118443 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C118443 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C118443 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118443 NCIT_P107 "Anti-fucosyl-GM1 Monoclonal Antibody BMS-986012" @default.
- NCIT_C118443 NCIT_P108 "Anti-fucosyl-GM1 Monoclonal Antibody BMS-986012" @default.
- NCIT_C118443 NCIT_P207 "C3896899" @default.
- NCIT_C118443 NCIT_P210 "1894272-37-7" @default.
- NCIT_C118443 NCIT_P319 "Q8PK97HY9B" @default.
- NCIT_C118443 NCIT_P322 "CTRP" @default.
- NCIT_C118443 NCIT_P322 "FDA" @default.
- NCIT_C118443 NCIT_P322 "GDC" @default.
- NCIT_C118443 NCIT_P329 "764995" @default.
- NCIT_C118443 NCIT_P330 "764995" @default.
- NCIT_C118443 NCIT_P375 "Anti-fucosyl-GM1 Monoclonal Antibody BMS-986012" @default.
- NCIT_C118443 NCIT_P399 "764995" @default.
- NCIT_C118443 NCIT_R124 NCIT_C17710 @default.
- NCIT_C118443 NCIT_R124 NCIT_C17828 @default.
- NCIT_C118443 NCIT_R124 NCIT_C18219 @default.
- NCIT_C118443 NCIT_R124 NCIT_C19986 @default.
- NCIT_C118443 NCIT_R124 NCIT_C40474 @default.
- NCIT_C118443 normalizedInformationContent "100" @default.
- NCIT_C118443 referenceCount "1" @default.
- NCIT_C118443 hasExactSynonym "Anti-fucosyl-GM1 Monoclonal Antibody BMS-986012" @default.
- NCIT_C118443 hasExactSynonym "BMS-986012" @default.
- NCIT_C118443 inSubset NCIT_C116977 @default.
- NCIT_C118443 inSubset NCIT_C116978 @default.
- NCIT_C118443 inSubset NCIT_C128784 @default.
- NCIT_C118443 inSubset NCIT_C157711 @default.
- NCIT_C118443 inSubset NCIT_C157712 @default.
- NCIT_C118443 inSubset NCIT_C176424 @default.
- NCIT_C118443 inSubset NCIT_C177537 @default.
- NCIT_C118443 inSubset NCIT_C63923 @default.
- NCIT_C118443 type Class @default.
- NCIT_C118443 isDefinedBy ncit.owl @default.
- NCIT_C118443 label "Anti-fucosyl-GM1 Monoclonal Antibody BMS-986012" @default.
- NCIT_C118443 subClassOf NCIT_C118443 @default.
- NCIT_C118443 subClassOf NCIT_C129821 @default.
- NCIT_C118443 subClassOf NCIT_C129822 @default.
- NCIT_C118443 subClassOf NCIT_C1908 @default.
- NCIT_C118443 subClassOf NCIT_C1909 @default.
- NCIT_C118443 subClassOf NCIT_C20401 @default.
- NCIT_C118443 subClassOf NCIT_C274 @default.
- NCIT_C118443 subClassOf NCIT_C307 @default.
- NCIT_C118443 subClassOf NCIT_C308 @default.