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- NCIT_C118446 IAO_0000115 "An orally bioavailable inhibitor of the serine protease dipeptidyl peptidase 4 (DPP-4), with hypoglycemic and potential renoprotective activities. Upon administration, gemigliptin binds to DPP-4 and inhibits the breakdown of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This prolongs incretin activity, increases postprandial insulin secretion from pancreatic beta cells, decreases glucagon secretion, delays gastric emptying and lowers blood glucose levels. In addition, gemigliptin exerts a renoprotective effect, probably through enhanced GLP-1 signaling, may prevent apoptosis and acute kidney injury induced by nephrotoxic agents, and may protect against diabetic nephropathy." @default.
- NCIT_C118446 NCIT_NHC0 "C118446" @default.
- NCIT_C118446 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118446 NCIT_P108 "Gemigliptin" @default.
- NCIT_C118446 NCIT_P207 "C2607564" @default.
- NCIT_C118446 NCIT_P210 "911637-19-9" @default.
- NCIT_C118446 NCIT_P319 "5DHU18M5D6" @default.
- NCIT_C118446 NCIT_P322 "FDA" @default.
- NCIT_C118446 NCIT_P329 "765050" @default.
- NCIT_C118446 NCIT_P330 "765050" @default.
- NCIT_C118446 NCIT_P399 "765050" @default.
- NCIT_C118446 normalizedInformationContent "100" @default.
- NCIT_C118446 referenceCount "1" @default.
- NCIT_C118446 hasExactSynonym "1-((2S)-2-Amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido(3,4-d)pyrimidin-7(6H)-yl)-4-oxobutyl-5,5-difluoropiperidin-2-one" @default.
- NCIT_C118446 hasExactSynonym "GEMIGLIPTIN" @default.
- NCIT_C118446 hasExactSynonym "Gemigliptin" @default.
- NCIT_C118446 hasExactSynonym "LC15-0444" @default.
- NCIT_C118446 inSubset NCIT_C176424 @default.
- NCIT_C118446 inSubset NCIT_C63923 @default.
- NCIT_C118446 type Class @default.
- NCIT_C118446 isDefinedBy ncit.owl @default.
- NCIT_C118446 label "Gemigliptin" @default.
- NCIT_C118446 subClassOf NCIT_C118446 @default.
- NCIT_C118446 subClassOf NCIT_C1908 @default.
- NCIT_C118446 subClassOf NCIT_C1909 @default.
- NCIT_C118446 subClassOf NCIT_C29711 @default.
- NCIT_C118446 subClassOf NCIT_C471 @default.
- NCIT_C118446 subClassOf NCIT_C78276 @default.
- NCIT_C118446 subClassOf NCIT_C783 @default.
- NCIT_C118446 subClassOf NCIT_C98086 @default.