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- NCIT_C118452 IAO_0000115 "A phytocannabinoid derived from Cannabis species, which is devoid of psychoactive activity, with analgesic, anti-inflammatory, antineoplastic and chemopreventive activities. Upon administration, cannabidiol (CBD) exerts its anti-proliferative, anti-angiogenic and pro-apoptotic activity through various mechanisms, which likely do not involve signaling by cannabinoid receptor 1 (CB1), CB2, or vanilloid receptor 1. CBD stimulates endoplasmic reticulum (ER) stress and inhibits AKT/mTOR signaling, thereby activating autophagy and promoting apoptosis. In addition, CBD enhances the generation of reactive oxygen species (ROS), which further enhances apoptosis. This agent also upregulates the expression of intercellular adhesion molecule 1 (ICAM-1) and tissue inhibitor of matrix metalloproteinases-1 (TIMP1) and decreases the expression of inhibitor of DNA binding 1 (ID-1). This inhibits cancer cell invasiveness and metastasis. CBD may also activate the transient receptor potential vanilloid type 2 (TRPV2), which may increase the uptake of various cytotoxic agents in cancer cells. The analgesic effect of CBD is mediated through the binding of this agent to and activation of CB1." @default.
- NCIT_C118452 NCIT_A32 NCIT_C1909 @default.
- NCIT_C118452 NCIT_NHC0 "C118452" @default.
- NCIT_C118452 NCIT_P106 "Organic Chemical" @default.
- NCIT_C118452 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C118452 NCIT_P107 "Cannabidiol" @default.
- NCIT_C118452 NCIT_P108 "Cannabidiol" @default.
- NCIT_C118452 NCIT_P207 "C0006863" @default.
- NCIT_C118452 NCIT_P210 "13956-29-1" @default.
- NCIT_C118452 NCIT_P319 "19GBJ60SN5" @default.
- NCIT_C118452 NCIT_P322 "CTRP" @default.
- NCIT_C118452 NCIT_P322 "DIPG/DMG" @default.
- NCIT_C118452 NCIT_P322 "FDA" @default.
- NCIT_C118452 NCIT_P322 "GDC" @default.
- NCIT_C118452 NCIT_P329 "765192" @default.
- NCIT_C118452 NCIT_P330 "765192" @default.
- NCIT_C118452 NCIT_P375 "Cannabidiol" @default.
- NCIT_C118452 NCIT_P399 "765192" @default.
- NCIT_C118452 normalizedInformationContent "100" @default.
- NCIT_C118452 referenceCount "1" @default.
- NCIT_C118452 hasExactSynonym "1,3-Benzenediol, 2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-, (1R-trans)-" @default.
- NCIT_C118452 hasExactSynonym "CANNABIDIOL" @default.
- NCIT_C118452 hasExactSynonym "CBD Oil" @default.
- NCIT_C118452 hasExactSynonym "CBD" @default.
- NCIT_C118452 hasExactSynonym "Cannabidiol" @default.
- NCIT_C118452 hasExactSynonym "Epidiolex" @default.
- NCIT_C118452 hasExactSynonym "GWP42003-P" @default.
- NCIT_C118452 inSubset NCIT_C116977 @default.
- NCIT_C118452 inSubset NCIT_C116978 @default.
- NCIT_C118452 inSubset NCIT_C128784 @default.
- NCIT_C118452 inSubset NCIT_C157711 @default.
- NCIT_C118452 inSubset NCIT_C157712 @default.
- NCIT_C118452 inSubset NCIT_C173381 @default.
- NCIT_C118452 inSubset NCIT_C173383 @default.
- NCIT_C118452 inSubset NCIT_C176424 @default.
- NCIT_C118452 inSubset NCIT_C177537 @default.
- NCIT_C118452 inSubset NCIT_C183079 @default.
- NCIT_C118452 inSubset NCIT_C63923 @default.
- NCIT_C118452 type Class @default.
- NCIT_C118452 isDefinedBy ncit.owl @default.
- NCIT_C118452 label "Cannabidiol" @default.
- NCIT_C118452 subClassOf NCIT_C105578 @default.
- NCIT_C118452 subClassOf NCIT_C118452 @default.
- NCIT_C118452 subClassOf NCIT_C1742 @default.
- NCIT_C118452 subClassOf NCIT_C1908 @default.
- NCIT_C118452 subClassOf NCIT_C1909 @default.
- NCIT_C118452 subClassOf NCIT_C1913 @default.
- NCIT_C118452 subClassOf NCIT_C1933 @default.
- NCIT_C118452 subClassOf NCIT_C2189 @default.
- NCIT_C118452 subClassOf NCIT_C274 @default.
- NCIT_C118452 subClassOf NCIT_C718 @default.